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The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes

The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes
The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes
Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function of some of these selenium-containing proteins remain poorly documented. Here, we found that selenoprotein T (SelT), a new thioredoxin-like protein, is regulated by the trophic neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in differentiating but not mature adrenomedullary cells. In fact, our analysis revealed that, in rat, SelT is highly expressed in most embryonic structures, and then its levels decreased progressively as these organs develop, to vanish in most adult tissues. In the brain, SelT was abundantly expressed in neural progenitors in various regions such as the cortex and cerebellum but was undetectable in adult nervous cells except rostral migratory-stream astrocytes and Bergmann cells. In contrast, SelT expression was maintained in several adult endocrine tissues such as pituitary, thyroid, or testis. In the pituitary gland, SelT was found in secretory cells of the anterior lobe, whereas in the testis, the selenoprotein was present only in spermatogenic and Leydig cells. Finally, we found that SelT expression is strongly stimulated in liver cells during the regenerative process that occurs after partial hepatectomy. Taken together, these data show that SelT induction is associated with ontogenesis, tissue maturation, and regenerative mechanisms, indicating that this PACAP-regulated selenoprotein may play a crucial role in cell growth and activity in nervous, endocrine, and metabolic tissues.
0013-7227
4322-4335
Tanguy, Yannick
1ed90f89-e18e-4615-9b97-4c9ae5ff2718
Falluel-Morel, Anthony
a798e50d-8bb3-456d-bbb5-0949658b3294
Arthaud, Sébastien
6620cb48-d385-49aa-ae36-ea2325f11e36
Boukhzar, Loubna
5bd6071e-0572-4625-869b-9ef69f915743
Manecka, Destiny-Love
867ac02d-238e-40c2-883f-2eb4b105487a
Chagraoui, Abdeslam
aeb7ba0c-84b0-4623-aec3-f45f039420ee
Prevost, Gaetan
8a9b01f3-253a-4fd2-96ef-7494e820b30f
Elias, Salah
a9b11116-8efb-44b3-8241-2f0f2af847c3
Dorval-Coiffec, Isabelle
828e284f-857e-462e-9eca-d1fab3f51a7b
Lesage, Jean
48084e41-ee75-49e1-864c-6b338bfe231e
Vieau, Didier
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Lihrmann, Isabelle
b020b4e9-419c-4f8f-bb68-a574d599d62a
Jégou, Bernard
4c174252-4789-4ef2-ac5b-d653135176aa
Anouar, Youssef
a19c61e2-e59d-417f-981b-f88eccf492b2
Tanguy, Yannick
1ed90f89-e18e-4615-9b97-4c9ae5ff2718
Falluel-Morel, Anthony
a798e50d-8bb3-456d-bbb5-0949658b3294
Arthaud, Sébastien
6620cb48-d385-49aa-ae36-ea2325f11e36
Boukhzar, Loubna
5bd6071e-0572-4625-869b-9ef69f915743
Manecka, Destiny-Love
867ac02d-238e-40c2-883f-2eb4b105487a
Chagraoui, Abdeslam
aeb7ba0c-84b0-4623-aec3-f45f039420ee
Prevost, Gaetan
8a9b01f3-253a-4fd2-96ef-7494e820b30f
Elias, Salah
a9b11116-8efb-44b3-8241-2f0f2af847c3
Dorval-Coiffec, Isabelle
828e284f-857e-462e-9eca-d1fab3f51a7b
Lesage, Jean
48084e41-ee75-49e1-864c-6b338bfe231e
Vieau, Didier
36fba5df-b730-4e00-80f8-c13ac85ac8dc
Lihrmann, Isabelle
b020b4e9-419c-4f8f-bb68-a574d599d62a
Jégou, Bernard
4c174252-4789-4ef2-ac5b-d653135176aa
Anouar, Youssef
a19c61e2-e59d-417f-981b-f88eccf492b2

Tanguy, Yannick, Falluel-Morel, Anthony, Arthaud, Sébastien, Boukhzar, Loubna, Manecka, Destiny-Love, Chagraoui, Abdeslam, Prevost, Gaetan, Elias, Salah, Dorval-Coiffec, Isabelle, Lesage, Jean, Vieau, Didier, Lihrmann, Isabelle, Jégou, Bernard and Anouar, Youssef (2011) The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Endocrinology, 152 (11), 4322-4335. (doi:10.1210/en.2011-1246).

Record type: Article

Abstract

Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function of some of these selenium-containing proteins remain poorly documented. Here, we found that selenoprotein T (SelT), a new thioredoxin-like protein, is regulated by the trophic neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in differentiating but not mature adrenomedullary cells. In fact, our analysis revealed that, in rat, SelT is highly expressed in most embryonic structures, and then its levels decreased progressively as these organs develop, to vanish in most adult tissues. In the brain, SelT was abundantly expressed in neural progenitors in various regions such as the cortex and cerebellum but was undetectable in adult nervous cells except rostral migratory-stream astrocytes and Bergmann cells. In contrast, SelT expression was maintained in several adult endocrine tissues such as pituitary, thyroid, or testis. In the pituitary gland, SelT was found in secretory cells of the anterior lobe, whereas in the testis, the selenoprotein was present only in spermatogenic and Leydig cells. Finally, we found that SelT expression is strongly stimulated in liver cells during the regenerative process that occurs after partial hepatectomy. Taken together, these data show that SelT induction is associated with ontogenesis, tissue maturation, and regenerative mechanisms, indicating that this PACAP-regulated selenoprotein may play a crucial role in cell growth and activity in nervous, endocrine, and metabolic tissues.

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Published date: 1 November 2011
Organisations: Biomedicine

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Local EPrints ID: 408242
URI: https://eprints.soton.ac.uk/id/eprint/408242
ISSN: 0013-7227
PURE UUID: c623e020-d010-426f-a529-94996f2cc5da

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Date deposited: 18 May 2017 04:01
Last modified: 25 Sep 2019 16:32

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Contributors

Author: Yannick Tanguy
Author: Anthony Falluel-Morel
Author: Sébastien Arthaud
Author: Loubna Boukhzar
Author: Destiny-Love Manecka
Author: Abdeslam Chagraoui
Author: Gaetan Prevost
Author: Salah Elias
Author: Isabelle Dorval-Coiffec
Author: Jean Lesage
Author: Didier Vieau
Author: Isabelle Lihrmann
Author: Bernard Jégou
Author: Youssef Anouar

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