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Addressing unmet needs in understanding asthma mechanisms

Addressing unmet needs in understanding asthma mechanisms
Addressing unmet needs in understanding asthma mechanisms
Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.
Edwards, Michael
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Saglani, Sejal
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Schwarze, Jurgen
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Skevaki, Chrysanthi
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Smith, Jaclyn
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Ainsworth, Ben
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Almond, Mark
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Andreakos, Evangelos
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Belvisi, Maria
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Chung, Kian Fan
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Cookson, William
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Cullinan, Paul
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Hawrylowicz, Catherine
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Lommatzsch, Marek
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Jackson, David
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Lutter, Rene
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Marsland, Benjamin
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Moffat, Miriam
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Thomas, Mike
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Virchow, J. Christian
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Xanthou, Georgina
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Edwards, Jessica
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Walker, Samantha
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Johnston, Sebastian L.
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EARIP WP2 Working Group
Edwards, Michael
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Saglani, Sejal
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Schwarze, Jurgen
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Skevaki, Chrysanthi
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Smith, Jaclyn
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Ainsworth, Ben
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Almond, Mark
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Andreakos, Evangelos
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Belvisi, Maria
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Chung, Kian Fan
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Cookson, William
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Cullinan, Paul
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Hawrylowicz, Catherine
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Lommatzsch, Marek
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Jackson, David
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Lutter, Rene
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Marsland, Benjamin
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Moffat, Miriam
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Thomas, Mike
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Virchow, J. Christian
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Xanthou, Georgina
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Edwards, Jessica
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Walker, Samantha
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Johnston, Sebastian L.
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Edwards, Michael, Saglani, Sejal, Schwarze, Jurgen, Skevaki, Chrysanthi, Smith, Jaclyn, Ainsworth, Ben, Almond, Mark, Andreakos, Evangelos, Belvisi, Maria, Chung, Kian Fan, Cookson, William, Cullinan, Paul, Hawrylowicz, Catherine, Lommatzsch, Marek, Jackson, David, Lutter, Rene, Marsland, Benjamin, Moffat, Miriam, Thomas, Mike, Virchow, J. Christian, Xanthou, Georgina, Edwards, Jessica, Walker, Samantha and Johnston, Sebastian L. , EARIP WP2 Working Group (2017) Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal, 49 (5). (doi:10.1183/13993003.02448-2016).

Record type: Article

Abstract

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

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erj_accepted_mansuscript - Accepted Manuscript
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Accepted/In Press date: 13 March 2017
e-pub ahead of print date: 1 May 2017
Organisations: Primary Care & Population Sciences, Human Wellbeing

Identifiers

Local EPrints ID: 408600
URI: https://eprints.soton.ac.uk/id/eprint/408600
PURE UUID: bd507483-be84-4361-99ff-3a3192e4bfad
ORCID for Ben Ainsworth: ORCID iD orcid.org/0000-0002-5098-1092

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Date deposited: 25 May 2017 04:02
Last modified: 20 Jul 2019 05:09

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Contributors

Author: Michael Edwards
Author: Sejal Saglani
Author: Jurgen Schwarze
Author: Chrysanthi Skevaki
Author: Jaclyn Smith
Author: Ben Ainsworth ORCID iD
Author: Mark Almond
Author: Evangelos Andreakos
Author: Maria Belvisi
Author: Kian Fan Chung
Author: William Cookson
Author: Paul Cullinan
Author: Catherine Hawrylowicz
Author: Marek Lommatzsch
Author: David Jackson
Author: Rene Lutter
Author: Benjamin Marsland
Author: Miriam Moffat
Author: Mike Thomas
Author: J. Christian Virchow
Author: Georgina Xanthou
Author: Jessica Edwards
Author: Samantha Walker
Author: Sebastian L. Johnston

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