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Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease

Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease
Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease

BACKGROUND: Ménière's disease (MD) is a debilitating disorder of the inner ear characterized by cochlear and vestibular dysfunction. The cause of this disease is still unknown, and epidemiological data for MD are sparse. From the existing literature, women seem to be more susceptible than men, and Caucasians seem to be more susceptible than Asians.

OBJECTIVE: In this article, we characterize a large definite MD cohort for sex and age of onset of disease and use molecular genetic methodologies to characterize ethnicity.

STUDY DESIGN: Medical record review for sex and age of onset. Ancestry analysis compared results from the principal component analysis of whole-genome genotype data from MD patients to self-identified ancestry in control samples.

SETTING: House Clinic in Los Angeles.

PATIENTS: Definitive MD patients.

RESULTS: Our review of medical records for definitive MD patients reveals that women are more susceptible than men. We also find that men and women have nearly identical age of onset for disease. Lastly, interrogation of molecular genetic data with principal component analysis allowed detailed observations about the ethnic ancestry of our patients. Comparison of the ethnicity of MD patients presenting to our tertiary care clinic with the self-recollected ethnicity of all patients visiting the clinic revealed an ethnic bias, with Caucasians presenting at a higher frequency than expected and the remaining major ethnicities populating Los Angeles (Hispanics, Blacks, and Asians) presenting at a lower frequency than expected.

CONCLUSION: To the best of our knowledge, this report is the first ethnic characterization of a large MD cohort from a large metropolitan region using molecular genetic data. Our data suggest that there is a bias in sex and ethnic susceptibility to this disease.

Adolescent, Adult, African Continental Ancestry Group, Age of Onset, Aged, Asian Continental Ancestry Group, Child, Cluster Analysis, Cohort Studies, DNA, Data Interpretation, Statistical, Epidemiologic Methods, Ethnic Groups, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome, Human, Genotype, Hispanic Americans, Humans, Male, Meniere Disease, Middle Aged, Principal Component Analysis, Sex Characteristics, Young Adult, Journal Article
1531-7129
1336-41
Ohmen, Jeffrey Douglass
eee13bf0-31d5-44f1-a8d1-9c6cefe09417
White, Cory H
45233a78-f0c9-4696-8aaf-1b2673f83c91
Li, Xin
50870cd7-3ec3-434e-a43a-b10d50e3d5b3
Wang, Juemei
c218cf75-9f66-4537-a71b-dc4e257654b4
Fisher, Laurel M
03e2a481-3d6b-4254-aca5-5e814865af2d
Zhang, Huan
93a95cf3-1feb-4e4a-acf9-0928617b26f9
Derebery, Mary Jennifer
c7cfa043-c547-4495-b7ed-38a6b4a576dd
Friedman, Rick A
1500f8c3-af23-4558-bf96-b045fc280997
Ohmen, Jeffrey Douglass
eee13bf0-31d5-44f1-a8d1-9c6cefe09417
White, Cory H
45233a78-f0c9-4696-8aaf-1b2673f83c91
Li, Xin
50870cd7-3ec3-434e-a43a-b10d50e3d5b3
Wang, Juemei
c218cf75-9f66-4537-a71b-dc4e257654b4
Fisher, Laurel M
03e2a481-3d6b-4254-aca5-5e814865af2d
Zhang, Huan
93a95cf3-1feb-4e4a-acf9-0928617b26f9
Derebery, Mary Jennifer
c7cfa043-c547-4495-b7ed-38a6b4a576dd
Friedman, Rick A
1500f8c3-af23-4558-bf96-b045fc280997

Ohmen, Jeffrey Douglass, White, Cory H, Li, Xin, Wang, Juemei, Fisher, Laurel M, Zhang, Huan, Derebery, Mary Jennifer and Friedman, Rick A (2013) Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otology & Neurotology, 34 (7), 1336-41. (doi:10.1097/MAO.0b013e3182868818).

Record type: Article

Abstract

BACKGROUND: Ménière's disease (MD) is a debilitating disorder of the inner ear characterized by cochlear and vestibular dysfunction. The cause of this disease is still unknown, and epidemiological data for MD are sparse. From the existing literature, women seem to be more susceptible than men, and Caucasians seem to be more susceptible than Asians.

OBJECTIVE: In this article, we characterize a large definite MD cohort for sex and age of onset of disease and use molecular genetic methodologies to characterize ethnicity.

STUDY DESIGN: Medical record review for sex and age of onset. Ancestry analysis compared results from the principal component analysis of whole-genome genotype data from MD patients to self-identified ancestry in control samples.

SETTING: House Clinic in Los Angeles.

PATIENTS: Definitive MD patients.

RESULTS: Our review of medical records for definitive MD patients reveals that women are more susceptible than men. We also find that men and women have nearly identical age of onset for disease. Lastly, interrogation of molecular genetic data with principal component analysis allowed detailed observations about the ethnic ancestry of our patients. Comparison of the ethnicity of MD patients presenting to our tertiary care clinic with the self-recollected ethnicity of all patients visiting the clinic revealed an ethnic bias, with Caucasians presenting at a higher frequency than expected and the remaining major ethnicities populating Los Angeles (Hispanics, Blacks, and Asians) presenting at a lower frequency than expected.

CONCLUSION: To the best of our knowledge, this report is the first ethnic characterization of a large MD cohort from a large metropolitan region using molecular genetic data. Our data suggest that there is a bias in sex and ethnic susceptibility to this disease.

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More information

Published date: September 2013
Keywords: Adolescent, Adult, African Continental Ancestry Group, Age of Onset, Aged, Asian Continental Ancestry Group, Child, Cluster Analysis, Cohort Studies, DNA, Data Interpretation, Statistical, Epidemiologic Methods, Ethnic Groups, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome, Human, Genotype, Hispanic Americans, Humans, Male, Meniere Disease, Middle Aged, Principal Component Analysis, Sex Characteristics, Young Adult, Journal Article
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 409386
URI: http://eprints.soton.ac.uk/id/eprint/409386
ISSN: 1531-7129
PURE UUID: 9365aff9-fd1f-4393-8396-e09e9e57a34c

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Date deposited: 28 May 2017 04:08
Last modified: 22 Jul 2022 21:24

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Contributors

Author: Jeffrey Douglass Ohmen
Author: Cory H White
Author: Xin Li
Author: Juemei Wang
Author: Laurel M Fisher
Author: Huan Zhang
Author: Mary Jennifer Derebery
Author: Rick A Friedman

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