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Intramolecular epoxide ring opening cyclisation reactions involving guanidines

Intramolecular epoxide ring opening cyclisation reactions involving guanidines
Intramolecular epoxide ring opening cyclisation reactions involving guanidines
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.
0040-4020
845-852
Al Shuhaib, Zainab
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Arndt, Marcel
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Dennis, Mark
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Evans, Daniel M.
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Jones, Iestyn
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Leitmann, Vera
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Murphy, Patrick J.
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Roberts, Dion
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Rowles, Richard
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Sadaghiani, Yones K.
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Thornhill, Andrew J.
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Nash, Robert J.
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Hollinshead, Jackie
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Batholomew, Barbara
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Tizzard, Graham J.
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Coles, Simon J.
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Al Shuhaib, Zainab
6dd6c8ad-7bb9-4aad-9f1b-db11edb458bb
Arndt, Marcel
57e0d0bb-d642-413e-9a28-224374451cf1
Dennis, Mark
aeb7123e-786d-4ae2-bc21-72eddd61697b
Evans, Daniel M.
097189a5-9c0b-4774-a48a-3a04e02c6f07
Jones, Iestyn
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Leitmann, Vera
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Murphy, Patrick J.
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Roberts, Dion
6ee1def3-b15c-4d14-aa1a-9eb8b6133a8b
Rowles, Richard
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Sadaghiani, Yones K.
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Thornhill, Andrew J.
0d829833-e582-4a27-be68-f03af3a70e5d
Nash, Robert J.
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Hollinshead, Jackie
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Batholomew, Barbara
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Tizzard, Graham J.
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Coles, Simon J.
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Al Shuhaib, Zainab, Arndt, Marcel, Dennis, Mark, Evans, Daniel M., Jones, Iestyn, Leitmann, Vera, Murphy, Patrick J., Roberts, Dion, Rowles, Richard, Sadaghiani, Yones K., Thornhill, Andrew J., Nash, Robert J., Hollinshead, Jackie, Batholomew, Barbara, Tizzard, Graham J. and Coles, Simon J. (2017) Intramolecular epoxide ring opening cyclisation reactions involving guanidines. Tetrahedron, 73 (7), 845-852. (doi:10.1016/j.tet.2016.12.065).

Record type: Article

Abstract

The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.

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More information

Accepted/In Press date: 23 December 2016
e-pub ahead of print date: 27 December 2016
Published date: 16 February 2017
Organisations: Chemistry, Chemistry Research Support

Identifiers

Local EPrints ID: 410137
URI: http://eprints.soton.ac.uk/id/eprint/410137
ISSN: 0040-4020
PURE UUID: 7de6efd1-81b4-4c9e-9d97-cea00699694b
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 03 Jun 2017 04:03
Last modified: 16 Mar 2024 03:22

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Contributors

Author: Zainab Al Shuhaib
Author: Marcel Arndt
Author: Mark Dennis
Author: Daniel M. Evans
Author: Iestyn Jones
Author: Vera Leitmann
Author: Patrick J. Murphy
Author: Dion Roberts
Author: Richard Rowles
Author: Yones K. Sadaghiani
Author: Andrew J. Thornhill
Author: Robert J. Nash
Author: Jackie Hollinshead
Author: Barbara Batholomew
Author: Simon J. Coles ORCID iD

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