Intramolecular epoxide ring opening cyclisation reactions involving guanidines
Intramolecular epoxide ring opening cyclisation reactions involving guanidines
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.
845-852
Al Shuhaib, Zainab
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Arndt, Marcel
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Dennis, Mark
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Evans, Daniel M.
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Jones, Iestyn
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Leitmann, Vera
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Murphy, Patrick J.
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Roberts, Dion
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Rowles, Richard
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Sadaghiani, Yones K.
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Thornhill, Andrew J.
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Nash, Robert J.
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Hollinshead, Jackie
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Batholomew, Barbara
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Tizzard, Graham J.
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Coles, Simon J.
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16 February 2017
Al Shuhaib, Zainab
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Arndt, Marcel
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Dennis, Mark
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Evans, Daniel M.
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Jones, Iestyn
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Leitmann, Vera
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Murphy, Patrick J.
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Roberts, Dion
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Rowles, Richard
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Sadaghiani, Yones K.
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Thornhill, Andrew J.
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Nash, Robert J.
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Hollinshead, Jackie
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Batholomew, Barbara
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Tizzard, Graham J.
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Coles, Simon J.
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Al Shuhaib, Zainab, Arndt, Marcel, Dennis, Mark, Evans, Daniel M., Jones, Iestyn, Leitmann, Vera, Murphy, Patrick J., Roberts, Dion, Rowles, Richard, Sadaghiani, Yones K., Thornhill, Andrew J., Nash, Robert J., Hollinshead, Jackie, Batholomew, Barbara, Tizzard, Graham J. and Coles, Simon J.
(2017)
Intramolecular epoxide ring opening cyclisation reactions involving guanidines.
Tetrahedron, 73 (7), .
(doi:10.1016/j.tet.2016.12.065).
Abstract
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.
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Accepted/In Press date: 23 December 2016
e-pub ahead of print date: 27 December 2016
Published date: 16 February 2017
Organisations:
Chemistry, Chemistry Research Support
Identifiers
Local EPrints ID: 410137
URI: http://eprints.soton.ac.uk/id/eprint/410137
ISSN: 0040-4020
PURE UUID: 7de6efd1-81b4-4c9e-9d97-cea00699694b
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Date deposited: 03 Jun 2017 04:03
Last modified: 16 Mar 2024 03:22
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Contributors
Author:
Zainab Al Shuhaib
Author:
Marcel Arndt
Author:
Mark Dennis
Author:
Daniel M. Evans
Author:
Iestyn Jones
Author:
Vera Leitmann
Author:
Patrick J. Murphy
Author:
Dion Roberts
Author:
Richard Rowles
Author:
Yones K. Sadaghiani
Author:
Andrew J. Thornhill
Author:
Robert J. Nash
Author:
Jackie Hollinshead
Author:
Barbara Batholomew
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