The University of Southampton
University of Southampton Institutional Repository

Intramolecular epoxide ring opening cyclisation reactions involving guanidines

Intramolecular epoxide ring opening cyclisation reactions involving guanidines
Intramolecular epoxide ring opening cyclisation reactions involving guanidines
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.
0040-4020
845-852
Al Shuhaib, Zainab
6dd6c8ad-7bb9-4aad-9f1b-db11edb458bb
Arndt, Marcel
57e0d0bb-d642-413e-9a28-224374451cf1
Dennis, Mark
aeb7123e-786d-4ae2-bc21-72eddd61697b
Evans, Daniel M.
097189a5-9c0b-4774-a48a-3a04e02c6f07
Jones, Iestyn
12baf86f-38a8-4626-a958-d2fe550e03bf
Leitmann, Vera
c862c23a-b1d6-4dac-bda3-4b3350d0944d
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Roberts, Dion
6ee1def3-b15c-4d14-aa1a-9eb8b6133a8b
Rowles, Richard
49ee7828-99ba-4f6c-985e-c13e8a5d05b3
Sadaghiani, Yones K.
5c57e5de-969b-4d2d-a3a6-8ef06a6ecc87
Thornhill, Andrew J.
0d829833-e582-4a27-be68-f03af3a70e5d
Nash, Robert J.
c942ab2c-772d-4d17-b12d-c87d7dd78769
Hollinshead, Jackie
161303a4-2ce5-4e59-8ded-73086b54bb7f
Batholomew, Barbara
5d490962-b82b-4e4c-b42c-e3e33276579a
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Al Shuhaib, Zainab
6dd6c8ad-7bb9-4aad-9f1b-db11edb458bb
Arndt, Marcel
57e0d0bb-d642-413e-9a28-224374451cf1
Dennis, Mark
aeb7123e-786d-4ae2-bc21-72eddd61697b
Evans, Daniel M.
097189a5-9c0b-4774-a48a-3a04e02c6f07
Jones, Iestyn
12baf86f-38a8-4626-a958-d2fe550e03bf
Leitmann, Vera
c862c23a-b1d6-4dac-bda3-4b3350d0944d
Murphy, Patrick J.
5ab567ae-c42c-44d4-8ae4-8b376cf2e6e6
Roberts, Dion
6ee1def3-b15c-4d14-aa1a-9eb8b6133a8b
Rowles, Richard
49ee7828-99ba-4f6c-985e-c13e8a5d05b3
Sadaghiani, Yones K.
5c57e5de-969b-4d2d-a3a6-8ef06a6ecc87
Thornhill, Andrew J.
0d829833-e582-4a27-be68-f03af3a70e5d
Nash, Robert J.
c942ab2c-772d-4d17-b12d-c87d7dd78769
Hollinshead, Jackie
161303a4-2ce5-4e59-8ded-73086b54bb7f
Batholomew, Barbara
5d490962-b82b-4e4c-b42c-e3e33276579a
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8

Al Shuhaib, Zainab, Arndt, Marcel, Dennis, Mark, Evans, Daniel M., Jones, Iestyn, Leitmann, Vera, Murphy, Patrick J., Roberts, Dion, Rowles, Richard, Sadaghiani, Yones K., Thornhill, Andrew J., Nash, Robert J., Hollinshead, Jackie, Batholomew, Barbara, Tizzard, Graham J. and Coles, Simon J. (2017) Intramolecular epoxide ring opening cyclisation reactions involving guanidines Tetrahedron, 73, (7), pp. 845-852. (doi:10.1016/j.tet.2016.12.065).

Record type: Article

Abstract

The cyclisation of N-allyl- and N-homoallylguanidines using DMDO leading to the formation of novel 5- and 6-membered guanidine heterocycles is reported. Several of the products formed displayed weak inhibition of glycosidase enzymes.

PDF 1-s2.0-S004040201631362X-main - Version of Record
Restricted to Repository staff only

More information

Accepted/In Press date: 23 December 2016
e-pub ahead of print date: 27 December 2016
Published date: 16 February 2017
Organisations: Chemistry, Chemistry Research Support

Identifiers

Local EPrints ID: 410137
URI: http://eprints.soton.ac.uk/id/eprint/410137
ISSN: 0040-4020
PURE UUID: 7de6efd1-81b4-4c9e-9d97-cea00699694b
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 03 Jun 2017 04:03
Last modified: 17 Jul 2017 14:00

Export record

Altmetrics

Contributors

Author: Zainab Al Shuhaib
Author: Marcel Arndt
Author: Mark Dennis
Author: Daniel M. Evans
Author: Iestyn Jones
Author: Vera Leitmann
Author: Patrick J. Murphy
Author: Dion Roberts
Author: Richard Rowles
Author: Yones K. Sadaghiani
Author: Andrew J. Thornhill
Author: Robert J. Nash
Author: Jackie Hollinshead
Author: Barbara Batholomew
Author: Simon J. Coles ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×