Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability

Castellanos, F.X., Sonuga-Barke, E.J.S., Scheres, A., Di Martino, A., Hyde, C. and Walters, J.R. (2005) Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability The World Journal of Biological Psychiatry, 57, (11), pp. 1224-1230. (doi:10.1016/j.biopsych.2004.12.005).


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Intra-individual variability in behavior and functioning is ubiquitous among children with attention-deficit/hyperactivity disorder (ADHD), but it has not been systematically examined or integrated within causal models. This article seeks to provide a conceptual, methodologic, and analytic framework as a foundation for future research. We first identify five key research questions and methodologic issues. For illustration, we examine the periodic structure of Eriksen Flanker task reaction time (RT) data obtained from 24 boys with ADHD and 18 age-matched comparison boys. Reaction time variability in ADHD differed quantitatively from control subjects, particularly at a modal frequency around .05 Hz (cycle length approximately 20 sec). These oscillations in RT were unaffected by double-blind placebo and were suppressed by double-blind methylphenidate. Together with converging lines of basic and clinical evidence, these secondary data analyses support the speculative hypothesis that the increased power of multisecond oscillations in ADHD RT data, and by inference, in attentional performance, represents a catecholaminergic deficit in the ability to appropriately modulate such oscillations in neuronal activity. These results highlight the importance of retaining time-series data and quantitatively examining intra-subject measures of variability as a putative endophenotype for ADHD.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.biopsych.2004.12.005
ISSNs: 1562-2975 (print)
Related URLs:
Keywords: attention-deficit/hyperactivity disorder, time-series analyses, fast Fourier transform, endophenotypes, reaction time, variability, morlet wavelet
ePrint ID: 41017
Date :
Date Event
Date Deposited: 13 Jul 2006
Last Modified: 16 Apr 2017 21:50
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