Diabetes is a risk factor for knee osteoarthritis progression
Diabetes is a risk factor for knee osteoarthritis progression
PURPOSE:Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA). We investigated their impact on radiographic progression by an annualised measure of the joint space narrowing (JSN) of the medial tibiofemoral compartment.
METHODS:559 patients older than 50 years with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial. The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. Body mass index (BMI) was calculated, obesity was considered >30 kg/m(2). MetS was defined by the sum of metabolic factors ≥ 3. Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 years.
RESULTS:The mean age of patients was 62.8 [62.2-63.4] years; 392 were women. A total of 43.8% was obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS. Mean annualised JSN was greater for patients with type 2 diabetes than without diabetes (0.26 [-0.35 to -0.17] vs 0.14 [-0.16 to -0.12] mm; P = 0.001). This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (P = 0.018). In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females. The other metabolic factors and MetS were not associated with annualised JSN.
CONCLUSION:Type 2 diabetes was a predictor of joint space reduction in men with established knee OA. No relationships were found between MetS or other metabolic factors and radiographic progression.
Diabetes; Knee osteoarthritis; Metabolic syndrome; Obesity; Radiological progression
851-859
Eymard, F.
2265cc6f-025b-48ef-b7d0-c939aa0860bd
Parsons, C.
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Edwards, M.H.
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Petit Dop, F.
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Reginster, J.-Y.
db56b103-184d-46e1-9600-f47f7a09a492
Bruyere, O.
7d127754-d7d6-4328-8f76-212df27727b6
Richette, P.
81184c8f-3602-4bf4-93ca-dc720d42f6c1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Chevalier, X.
c1ff9aea-e2ee-4c00-a499-70d892d3c428
June 2015
Eymard, F.
2265cc6f-025b-48ef-b7d0-c939aa0860bd
Parsons, C.
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Petit Dop, F.
0af40637-efb0-4e14-a41f-9a6c9f891916
Reginster, J.-Y.
db56b103-184d-46e1-9600-f47f7a09a492
Bruyere, O.
7d127754-d7d6-4328-8f76-212df27727b6
Richette, P.
81184c8f-3602-4bf4-93ca-dc720d42f6c1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Chevalier, X.
c1ff9aea-e2ee-4c00-a499-70d892d3c428
Eymard, F., Parsons, C., Edwards, M.H., Petit Dop, F., Reginster, J.-Y., Bruyere, O., Richette, P., Cooper, C. and Chevalier, X.
(2015)
Diabetes is a risk factor for knee osteoarthritis progression.
Osteoarthritis and Cartilage, 23 (6), .
(doi:10.1016/j.joca.2015.01.013).
Abstract
PURPOSE:Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA). We investigated their impact on radiographic progression by an annualised measure of the joint space narrowing (JSN) of the medial tibiofemoral compartment.
METHODS:559 patients older than 50 years with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial. The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. Body mass index (BMI) was calculated, obesity was considered >30 kg/m(2). MetS was defined by the sum of metabolic factors ≥ 3. Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 years.
RESULTS:The mean age of patients was 62.8 [62.2-63.4] years; 392 were women. A total of 43.8% was obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS. Mean annualised JSN was greater for patients with type 2 diabetes than without diabetes (0.26 [-0.35 to -0.17] vs 0.14 [-0.16 to -0.12] mm; P = 0.001). This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (P = 0.018). In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females. The other metabolic factors and MetS were not associated with annualised JSN.
CONCLUSION:Type 2 diabetes was a predictor of joint space reduction in men with established knee OA. No relationships were found between MetS or other metabolic factors and radiographic progression.
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More information
Accepted/In Press date: 23 January 2015
e-pub ahead of print date: 3 February 2015
Published date: June 2015
Keywords:
Diabetes; Knee osteoarthritis; Metabolic syndrome; Obesity; Radiological progression
Organisations:
Epidemiology, Medical Research Council, Human Development & Health
Identifiers
Local EPrints ID: 410436
URI: http://eprints.soton.ac.uk/id/eprint/410436
ISSN: 1063-4584
PURE UUID: c3ba093b-8e24-4eb2-9abf-346a5139e1b5
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Date deposited: 08 Jun 2017 16:31
Last modified: 18 Mar 2024 02:46
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Contributors
Author:
F. Eymard
Author:
C. Parsons
Author:
M.H. Edwards
Author:
F. Petit Dop
Author:
J.-Y. Reginster
Author:
O. Bruyere
Author:
P. Richette
Author:
X. Chevalier
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