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High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing: The SEKOIA Study

High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing: The SEKOIA Study
High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing: The SEKOIA Study
OBJECTIVE: Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW).

METHODS: A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression.

RESULTS: The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = -0.10 (95% CI -0.18, -0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW.

CONCLUSION: The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade.
JOINT SPACE NARROWING; KNEE; MAGNETIC RESONANCE IMAGING; NATURAL HISTORY; OSTEOARTHRITIS; PROGRESSION; RADIOGRAPHIC
0315-162X
657-665
Edwards, Mark H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Bruyere, Olivier
7d127754-d7d6-4328-8f76-212df27727b6
Petit Dop, Florence
0af40637-efb0-4e14-a41f-9a6c9f891916
Chapurlat, Roland
d9410f8c-4e4a-465b-8fb6-67efaadaad4c
Roemer, F
25b2abc1-b7b7-4966-8fac-a4799902eddc
Guermazi, A.
b2164f06-6621-449a-8319-eeff0ce9d0ad
Zaim, S.
4956a057-8245-4b51-8766-3140d4116257
Genant, H.
d5e63c14-a724-4233-9b54-6c9354b9ffe7
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Edwards, Mark H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Bruyere, Olivier
7d127754-d7d6-4328-8f76-212df27727b6
Petit Dop, Florence
0af40637-efb0-4e14-a41f-9a6c9f891916
Chapurlat, Roland
d9410f8c-4e4a-465b-8fb6-67efaadaad4c
Roemer, F
25b2abc1-b7b7-4966-8fac-a4799902eddc
Guermazi, A.
b2164f06-6621-449a-8319-eeff0ce9d0ad
Zaim, S.
4956a057-8245-4b51-8766-3140d4116257
Genant, H.
d5e63c14-a724-4233-9b54-6c9354b9ffe7
Reginster, Jean-Yves
db56b103-184d-46e1-9600-f47f7a09a492
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Edwards, Mark H., Parsons, Camille, Bruyere, Olivier, Petit Dop, Florence, Chapurlat, Roland, Roemer, F, Guermazi, A., Zaim, S., Genant, H., Reginster, Jean-Yves, Dennison, Elaine and Cooper, Cyrus (2016) High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing: The SEKOIA Study. The Journal of Rheumatology, 43 (3), 657-665. (doi:10.3899/jrheum.150053).

Record type: Article

Abstract

OBJECTIVE: Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW).

METHODS: A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression.

RESULTS: The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = -0.10 (95% CI -0.18, -0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW.

CONCLUSION: The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade.

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More information

Accepted/In Press date: 11 September 2015
e-pub ahead of print date: 15 January 2016
Published date: March 2016
Keywords: JOINT SPACE NARROWING; KNEE; MAGNETIC RESONANCE IMAGING; NATURAL HISTORY; OSTEOARTHRITIS; PROGRESSION; RADIOGRAPHIC
Organisations: Epidemiology, Medical Research Council, Human Development & Health

Identifiers

Local EPrints ID: 410437
URI: http://eprints.soton.ac.uk/id/eprint/410437
ISSN: 0315-162X
PURE UUID: da5165a2-d9d4-4778-bdee-e8c736c7b6b1
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 08 Jun 2017 16:31
Last modified: 18 Feb 2021 16:48

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