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Specialisation in the medial temporal lobe for processing of objects and scenes

Specialisation in the medial temporal lobe for processing of objects and scenes
Specialisation in the medial temporal lobe for processing of objects and scenes
There has been considerable debate as to whether the hippocampus and perirhinal cortex may subserve both memory and perception. We administered a series of oddity tasks, in which subjects selected the odd stimulus from a visual array, to amnesic patients with either selective hippocampal damage (HC group) or more extensive medial temporal damage, including the perirhinal cortex (MTL group). All patients performed normally when the stimuli could be discriminated using simple visual features, even if faces or complex virtual reality scenes were presented. Both patient groups were, however, severely impaired at scene discrimination when a significant demand was placed on processing spatial information across viewpoint independent representations, while only the MTL group showed a significant deficit in oddity judgments of faces and objects when object viewpoint independent perception was emphasized. These observations provide compelling evidence that the human hippocampus and perirhinal cortex are critical to processes beyond long-term declarative memory and may subserve spatial and object perception, respectively
hippocampus, perirhinal cortex, perception, memory, amnesia
1050-9631
782-797
Lee, Andy C.H.
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Buckley, Mark J.
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Pegman, Sarah J.
a6901b6e-1115-4a96-8137-fac79d09f6b5
Spiers, Hugo
558afa7b-d842-4ca7-a66e-eff8e11f1538
Scahill, Victoria L.
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Gaffan, David
16cdb84c-df28-477b-9c8a-0ada33299f07
Bussey, Timothy J.
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Davies, R. Rhys
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Kapur, Narinder
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Hodges, John R.
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Graham, Kim S.
c0e0b047-099f-45ab-ade4-85f9f184f24b
Lee, Andy C.H.
0b32a44b-c751-4ecc-8a70-77d9c9bf30dd
Buckley, Mark J.
de068bc2-78c8-406c-93bd-8d92e83469f5
Pegman, Sarah J.
a6901b6e-1115-4a96-8137-fac79d09f6b5
Spiers, Hugo
558afa7b-d842-4ca7-a66e-eff8e11f1538
Scahill, Victoria L.
50478e52-032a-49cb-9163-38957696b44a
Gaffan, David
16cdb84c-df28-477b-9c8a-0ada33299f07
Bussey, Timothy J.
472f7e69-6465-4d88-9301-8c6e26fcae72
Davies, R. Rhys
72f141e9-b43d-46f8-acc4-1fa9976bc6cb
Kapur, Narinder
9ea5d758-bba6-4bc9-be6b-b056c0c83d9d
Hodges, John R.
7e7a95ab-a65f-42a1-8c01-30917e6b2f3d
Graham, Kim S.
c0e0b047-099f-45ab-ade4-85f9f184f24b

Lee, Andy C.H., Buckley, Mark J., Pegman, Sarah J., Spiers, Hugo, Scahill, Victoria L., Gaffan, David, Bussey, Timothy J., Davies, R. Rhys, Kapur, Narinder, Hodges, John R. and Graham, Kim S. (2005) Specialisation in the medial temporal lobe for processing of objects and scenes. Hippocampus, 15 (6), 782-797. (doi:10.1002/hipo.20101).

Record type: Article

Abstract

There has been considerable debate as to whether the hippocampus and perirhinal cortex may subserve both memory and perception. We administered a series of oddity tasks, in which subjects selected the odd stimulus from a visual array, to amnesic patients with either selective hippocampal damage (HC group) or more extensive medial temporal damage, including the perirhinal cortex (MTL group). All patients performed normally when the stimuli could be discriminated using simple visual features, even if faces or complex virtual reality scenes were presented. Both patient groups were, however, severely impaired at scene discrimination when a significant demand was placed on processing spatial information across viewpoint independent representations, while only the MTL group showed a significant deficit in oddity judgments of faces and objects when object viewpoint independent perception was emphasized. These observations provide compelling evidence that the human hippocampus and perirhinal cortex are critical to processes beyond long-term declarative memory and may subserve spatial and object perception, respectively

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More information

Published date: 2005
Keywords: hippocampus, perirhinal cortex, perception, memory, amnesia

Identifiers

Local EPrints ID: 41055
URI: http://eprints.soton.ac.uk/id/eprint/41055
ISSN: 1050-9631
PURE UUID: 905cd803-e326-4920-84f6-675ca8f628a4

Catalogue record

Date deposited: 14 Jul 2006
Last modified: 15 Jul 2019 18:58

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