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The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy – An immunological perspective

The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy – An immunological perspective
The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy – An immunological perspective

During normal pregnancy, the mechanism by which the fetus escapes immunological rejection by the maternal womb remains elusive. Given the biological complexities, the immunological mechanism is unlikely to be simply an allograft response in acceptance or rejection of the early pregnancy. Circadian clock responsible for the mammalian circadian rhythm is an endogenously generated rhythm associated with almost all physiological processes including reproduction. There is now growing evidence to suggest that the circadian clocks are intricately linked to the immune system and pregnancy. When perturbed, the role of immune cells can be affected on maintaining the enriched vascular system needed for placentation. This alteration can be triggered by the irregular production of maternal and placental melatonin. Hence, the role of circadian rhythm modulators such as melatonin offers intriguing opportunities for therapy. In this review, we evaluate the complex interaction between the circadian clock and melatonin within the immune system and their roles in the circadian regulation and maintenance of normal pregnancy.

circadian rhythm, immune repsonse, melatonin, placenta, pregnancy
8755-8920
Man, Gene Chi Wai
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Zhang, Tao
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Chen, Xiaoyan
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Wang, Jianzhang
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Wu, Fangrong
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Liu, Yingyu
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Wang, Chi Chiu
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Cheong, Ying
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Li, Tin Chiu
12800d17-18d8-44f0-89bc-e005ddec4d71
Man, Gene Chi Wai
98754bfb-b93d-4cb0-85f5-5a4972ccb5c1
Zhang, Tao
002b6b95-19d0-45ff-8718-34d4fb927203
Chen, Xiaoyan
e0bb63dc-c6dd-4e47-8233-4b6bbd4f9b7f
Wang, Jianzhang
1d80b69e-85d8-467f-940b-761efd5fab6d
Wu, Fangrong
882af2c3-f5b5-41a0-98fb-d1fde9a3c93a
Liu, Yingyu
b0973d5f-817e-4b8f-a5bd-659a1af515f5
Wang, Chi Chiu
43c9b131-8c39-437c-871b-26a772b96d8d
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Li, Tin Chiu
12800d17-18d8-44f0-89bc-e005ddec4d71

Man, Gene Chi Wai, Zhang, Tao, Chen, Xiaoyan, Wang, Jianzhang, Wu, Fangrong, Liu, Yingyu, Wang, Chi Chiu, Cheong, Ying and Li, Tin Chiu (2017) The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy – An immunological perspective. American Journal of Reproductive Immunology, 78 (2), [e12715]. (doi:10.1111/aji.12715).

Record type: Article

Abstract

During normal pregnancy, the mechanism by which the fetus escapes immunological rejection by the maternal womb remains elusive. Given the biological complexities, the immunological mechanism is unlikely to be simply an allograft response in acceptance or rejection of the early pregnancy. Circadian clock responsible for the mammalian circadian rhythm is an endogenously generated rhythm associated with almost all physiological processes including reproduction. There is now growing evidence to suggest that the circadian clocks are intricately linked to the immune system and pregnancy. When perturbed, the role of immune cells can be affected on maintaining the enriched vascular system needed for placentation. This alteration can be triggered by the irregular production of maternal and placental melatonin. Hence, the role of circadian rhythm modulators such as melatonin offers intriguing opportunities for therapy. In this review, we evaluate the complex interaction between the circadian clock and melatonin within the immune system and their roles in the circadian regulation and maintenance of normal pregnancy.

Text
AJRI-03-17-054.R1 - Accepted Manuscript
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More information

Accepted/In Press date: 4 May 2017
e-pub ahead of print date: 6 June 2017
Published date: August 2017
Keywords: circadian rhythm, immune repsonse, melatonin, placenta, pregnancy
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 410625
URI: http://eprints.soton.ac.uk/id/eprint/410625
ISSN: 8755-8920
PURE UUID: 371b7232-fca5-4a10-9b5a-9ed9971887c4
ORCID for Ying Cheong: ORCID iD orcid.org/0000-0001-7687-4597

Catalogue record

Date deposited: 09 Jun 2017 09:15
Last modified: 22 Nov 2021 05:25

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Contributors

Author: Gene Chi Wai Man
Author: Tao Zhang
Author: Xiaoyan Chen
Author: Jianzhang Wang
Author: Fangrong Wu
Author: Yingyu Liu
Author: Chi Chiu Wang
Author: Ying Cheong ORCID iD
Author: Tin Chiu Li

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