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Localized tissue mineralization regulated by bone remodelling: a computational approach

Localized tissue mineralization regulated by bone remodelling: a computational approach
Localized tissue mineralization regulated by bone remodelling: a computational approach
Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and mineralization, each sample of bone is composed of structural units (osteons in cortical and packets in cancellous bone) created at different times, therefore presenting different levels of mineral content. In this work, a computational model is used to understand the feedback between the remodelling and the mineralization processes under different load conditions and bone porosities. This model considers that osteoclasts primarily resorb those parts of bone closer to the surface, which are younger and less mineralized than older inner ones. Under equilibrium loads, results show that bone volumes with both the highest and the lowest levels of porosity (cancellous and cortical respectively) tend to develop higher levels of mineral content compared to volumes with intermediate porosity, thus presenting higher material densities. In good agreement with recent experimental measurements, a boomerang-like pattern emerges when plotting apparent density at the tissue level versus material density at the bone material level. Overload and disuse states are studied too, resulting in a translation of the apparent–material density curve. Numerical results are discussed pointing to potential clinical applications.
bone remodelling, mineralization patterns, material
1932-6203
Berli, Marcelo
e92bdb78-5f8c-4c6d-b918-ca3c54bac3c0
Borau, Carlos
d34d8bf3-6e2f-4915-acf3-530ceea90eeb
Decco, Oscar
db8a64b7-b8c5-4ced-9a95-53427cb49f4c
Adams, George
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Cook, Richard B.
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Garcia Aznar, Jose Manuel
352dc537-b794-4ebc-854c-f70968a3c2e3
Zioupos, Peter
70120765-7396-4e86-bb9e-9c4d64c43294
Berli, Marcelo
e92bdb78-5f8c-4c6d-b918-ca3c54bac3c0
Borau, Carlos
d34d8bf3-6e2f-4915-acf3-530ceea90eeb
Decco, Oscar
db8a64b7-b8c5-4ced-9a95-53427cb49f4c
Adams, George
4966cbc2-4181-412e-b547-6b48663f495f
Cook, Richard B.
06f8322d-81be-4f82-9326-19e55541c78f
Garcia Aznar, Jose Manuel
352dc537-b794-4ebc-854c-f70968a3c2e3
Zioupos, Peter
70120765-7396-4e86-bb9e-9c4d64c43294

Berli, Marcelo, Borau, Carlos, Decco, Oscar, Adams, George, Cook, Richard B., Garcia Aznar, Jose Manuel and Zioupos, Peter (2017) Localized tissue mineralization regulated by bone remodelling: a computational approach. PLoS ONE, 12 (3). (doi:10.1371/journal.pone.0173228).

Record type: Article

Abstract

Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and mineralization, each sample of bone is composed of structural units (osteons in cortical and packets in cancellous bone) created at different times, therefore presenting different levels of mineral content. In this work, a computational model is used to understand the feedback between the remodelling and the mineralization processes under different load conditions and bone porosities. This model considers that osteoclasts primarily resorb those parts of bone closer to the surface, which are younger and less mineralized than older inner ones. Under equilibrium loads, results show that bone volumes with both the highest and the lowest levels of porosity (cancellous and cortical respectively) tend to develop higher levels of mineral content compared to volumes with intermediate porosity, thus presenting higher material densities. In good agreement with recent experimental measurements, a boomerang-like pattern emerges when plotting apparent density at the tissue level versus material density at the bone material level. Overload and disuse states are studied too, resulting in a translation of the apparent–material density curve. Numerical results are discussed pointing to potential clinical applications.

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Accepted/In Press date: 18 February 2017
e-pub ahead of print date: 17 March 2017
Published date: 17 March 2017
Keywords: bone remodelling, mineralization patterns, material
Organisations: nCATS Group

Identifiers

Local EPrints ID: 410670
URI: https://eprints.soton.ac.uk/id/eprint/410670
ISSN: 1932-6203
PURE UUID: b2f9b181-30e4-4652-b3c9-a55a7dd8cccb

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Date deposited: 09 Jun 2017 09:20
Last modified: 13 Mar 2019 19:59

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