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TLR-3/9 agonists synergize with anti-ErbB2 mAb-Letter

TLR-3/9 agonists synergize with anti-ErbB2 mAb-Letter
TLR-3/9 agonists synergize with anti-ErbB2 mAb-Letter
Charlebois and colleagues recently reported that the antitumor activity of anti-ErbB2 mAb is enhanced by local polyI:C and CpG administration in murine breast tumor models (1) and concluded that this activity was dependent on IFNs, CD8+ T, and natural killer (NK) cells. The requirement for NK cells was based on in vivo depletion using anti-asialo-GM1 (ASGM1) Ab.
0008-5472
3376-3378
Turaj, Anna H.
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Dahal, Lekh N.
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Beers, Stephen A.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Lim, Sean H.
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Turaj, Anna H.
fbbc48ea-28cf-4db7-ae4a-c16ce7b3857a
Dahal, Lekh N.
1e993a7a-b007-4187-82ea-e28dd3920b66
Beers, Stephen A.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Cragg, Mark S.
ec97f80e-f3c8-49b7-a960-20dff648b78c
Lim, Sean H.
1afe5aa1-61a4-4a7b-927f-5e671f885196

Turaj, Anna H., Dahal, Lekh N., Beers, Stephen A., Cragg, Mark S. and Lim, Sean H. (2017) TLR-3/9 agonists synergize with anti-ErbB2 mAb-Letter. Cancer Research, 77 (12), 3376-3378. (doi:10.1158/0008-5472.CAN-17-0412).

Record type: Letter

Abstract

Charlebois and colleagues recently reported that the antitumor activity of anti-ErbB2 mAb is enhanced by local polyI:C and CpG administration in murine breast tumor models (1) and concluded that this activity was dependent on IFNs, CD8+ T, and natural killer (NK) cells. The requirement for NK cells was based on in vivo depletion using anti-asialo-GM1 (ASGM1) Ab.

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Cancer Research Letter resubmit 200317 - Accepted Manuscript
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Accepted/In Press date: 23 March 2017
e-pub ahead of print date: 5 June 2017
Published date: June 2017
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 410691
URI: http://eprints.soton.ac.uk/id/eprint/410691
ISSN: 0008-5472
PURE UUID: 77cd23ae-2cc5-408d-9251-e505a99db778
ORCID for Stephen A. Beers: ORCID iD orcid.org/0000-0002-3765-3342
ORCID for Mark S. Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 09 Jun 2017 09:22
Last modified: 16 Mar 2024 05:17

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Contributors

Author: Anna H. Turaj
Author: Lekh N. Dahal
Author: Mark S. Cragg ORCID iD
Author: Sean H. Lim

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