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Prebiotic effects of cocoa fibre on rats

Prebiotic effects of cocoa fibre on rats
Prebiotic effects of cocoa fibre on rats
The impact of cocoa on microbiota composition, its crosstalk with the immune system and the SCFA production, focusing on the involvement of cocoa fibre were investigated Wistar rats were fed for 3-weeks a standard diet, a diet containing 10%-cocoa (C10), cocoa fibre (CF) or inulin (I). Faecal and serum samples were collected before and after the intervention and caecal content and colon sample were collected at the end. Microbiota composition and IgA-coated bacteria and the SCFA content were quantified. The colonic expression of immune-related genes was studied. The CF diet increased Bifidobacterium and Lactobacillus counts, the proportion of IgA-coated bacteria, the SCFA concentrations and the TLR2, TLR5, TLR7 and occludin expression. With the exception on Lactobacillus counts, the I diet modified the other variables in a more modest way than the CF diet. The CF, unlike from the C10 diet, has prebiotic effects and modulates intestinal immune markers.
1756-4646
341-352
Massot-Cladera, Malen
0920c856-4210-44da-9fa7-806f6d2dcb83
Costabile, Adele
2f54d3f0-8414-4844-8296-e97f6097e09e
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Franch, Angels
71db5202-e1af-42bf-b46c-ec2a9438355b
Castell, Margarida
d5b54ea9-eb97-4dee-9dbf-a1b3b879736c
Pérez-Cano, Francisco J.
1e1617fa-972a-4559-9249-8c71048ca50e
Massot-Cladera, Malen
0920c856-4210-44da-9fa7-806f6d2dcb83
Costabile, Adele
2f54d3f0-8414-4844-8296-e97f6097e09e
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Franch, Angels
71db5202-e1af-42bf-b46c-ec2a9438355b
Castell, Margarida
d5b54ea9-eb97-4dee-9dbf-a1b3b879736c
Pérez-Cano, Francisco J.
1e1617fa-972a-4559-9249-8c71048ca50e

Massot-Cladera, Malen, Costabile, Adele, Childs, Caroline, Yaqoob, Parveen, Franch, Angels, Castell, Margarida and Pérez-Cano, Francisco J. (2015) Prebiotic effects of cocoa fibre on rats. Journal of Functional Foods, 19, 341-352. (doi:10.1016/j.jff.2015.09.021).

Record type: Article

Abstract

The impact of cocoa on microbiota composition, its crosstalk with the immune system and the SCFA production, focusing on the involvement of cocoa fibre were investigated Wistar rats were fed for 3-weeks a standard diet, a diet containing 10%-cocoa (C10), cocoa fibre (CF) or inulin (I). Faecal and serum samples were collected before and after the intervention and caecal content and colon sample were collected at the end. Microbiota composition and IgA-coated bacteria and the SCFA content were quantified. The colonic expression of immune-related genes was studied. The CF diet increased Bifidobacterium and Lactobacillus counts, the proportion of IgA-coated bacteria, the SCFA concentrations and the TLR2, TLR5, TLR7 and occludin expression. With the exception on Lactobacillus counts, the I diet modified the other variables in a more modest way than the CF diet. The CF, unlike from the C10 diet, has prebiotic effects and modulates intestinal immune markers.

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More information

Accepted/In Press date: 8 September 2015
e-pub ahead of print date: 30 September 2015
Published date: December 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 410699
URI: http://eprints.soton.ac.uk/id/eprint/410699
ISSN: 1756-4646
PURE UUID: 5e9dec8c-9baf-4a58-b58d-08b4d56c41ae
ORCID for Caroline Childs: ORCID iD orcid.org/0000-0001-6832-224X

Catalogue record

Date deposited: 09 Jun 2017 09:23
Last modified: 18 Feb 2021 17:11

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Contributors

Author: Malen Massot-Cladera
Author: Adele Costabile
Author: Caroline Childs ORCID iD
Author: Parveen Yaqoob
Author: Angels Franch
Author: Margarida Castell
Author: Francisco J. Pérez-Cano

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