Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography
Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography
Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.
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Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4
2016
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4
Mahmoudi, Michael and Curzen, Nicholas
(2016)
Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography.
Case Reports in Medicine, , [2096181].
(doi:10.1155/2016/2096181).
Abstract
Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.
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Stent Thrombosis ....
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Accepted/In Press date: 28 August 2016
Published date: 2016
Organisations:
Human Development & Health
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Local EPrints ID: 410985
URI: http://eprints.soton.ac.uk/id/eprint/410985
PURE UUID: 977b59cb-398f-4416-b456-88c6497d8555
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Date deposited: 12 Jun 2017 16:31
Last modified: 16 Mar 2024 05:23
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