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Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography

Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography
Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography
Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.
1-6
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Curzen, Nicholas
70f3ea49-51b1-418f-8e56-8210aef1abf4

Mahmoudi, Michael and Curzen, Nicholas (2016) Stent thrombosis patients with hyporesponsiveness to Clopidogrel, Prasugrel, and Ticagrelor: a case series using short thromboelastography. Case Reports in Medicine, 1-6, [2096181]. (doi:10.1155/2016/2096181).

Record type: Article

Abstract

Patients after percutaneous coronary intervention (PCI) with stent implantation and functional hyporesponsiveness to P2Y12 inhibitors are at higher risk of ischaemic events, particularly stent thrombosis (ST). It is currently not routine practice to assess the functional response to these agents. However, concern over functional hyporesponsiveness to clopidogrel has led to widespread uptake of prasugrel and ticagrelor as the default P2Y12 inhibitor after stent implantation in patients with acute coronary syndrome. Here we report, for the first time, 3 cases in which patients who have had ST exhibit hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor.

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Accepted/In Press date: 28 August 2016
Published date: 2016
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 410985
URI: http://eprints.soton.ac.uk/id/eprint/410985
PURE UUID: 977b59cb-398f-4416-b456-88c6497d8555
ORCID for Michael Mahmoudi: ORCID iD orcid.org/0000-0003-1293-8461
ORCID for Nicholas Curzen: ORCID iD orcid.org/0000-0001-9651-7829

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Date deposited: 12 Jun 2017 16:31
Last modified: 18 Feb 2021 17:26

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