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Intrinsic mechanisms regulating axon regeneration: an integrin perspective

Intrinsic mechanisms regulating axon regeneration: an integrin perspective
Intrinsic mechanisms regulating axon regeneration: an integrin perspective

Adult central nervous system (CNS) axons fail to regenerate after injury because of inhibitory factors in the surrounding environment and a low intrinsic regenerative capacity. Axons in the adult peripheral nervous system have a higher regenerative capacity, due in part to the presence of certain integrins-receptors for the extracellular matrix. Integrins are critical for axon growth during the development of the nervous system but are absent from some adult CNS axons. Here, we discuss the intrinsic mechanisms that regulate axon regeneration and examine the role of integrins. As correct localization is paramount to integrin function, we further discuss the mechanisms that regulate integrin traffic toward the axonal growth cone.

0074-7742
75-104
Eva, Richard
6a12b701-379b-4aed-97c8-06b21cbff960
Andrews, Melissa R
ae987a2f-878e-4ae3-a7a3-a7170712096c
Franssen, Elske H P
a20f900d-54de-4c75-a52c-d08193db8dd9
Fawcett, James W
4549730e-9f62-45b8-820b-8a9c98d1058b
Eva, Richard
6a12b701-379b-4aed-97c8-06b21cbff960
Andrews, Melissa R
ae987a2f-878e-4ae3-a7a3-a7170712096c
Franssen, Elske H P
a20f900d-54de-4c75-a52c-d08193db8dd9
Fawcett, James W
4549730e-9f62-45b8-820b-8a9c98d1058b

Eva, Richard, Andrews, Melissa R, Franssen, Elske H P and Fawcett, James W (2012) Intrinsic mechanisms regulating axon regeneration: an integrin perspective. International Review of Neurobiology, 106, 75-104. (doi:10.1016/B978-0-12-407178-0.00004-1).

Record type: Review

Abstract

Adult central nervous system (CNS) axons fail to regenerate after injury because of inhibitory factors in the surrounding environment and a low intrinsic regenerative capacity. Axons in the adult peripheral nervous system have a higher regenerative capacity, due in part to the presence of certain integrins-receptors for the extracellular matrix. Integrins are critical for axon growth during the development of the nervous system but are absent from some adult CNS axons. Here, we discuss the intrinsic mechanisms that regulate axon regeneration and examine the role of integrins. As correct localization is paramount to integrin function, we further discuss the mechanisms that regulate integrin traffic toward the axonal growth cone.

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Published date: 2012
Organisations: Biomedicine

Identifiers

Local EPrints ID: 411077
URI: http://eprints.soton.ac.uk/id/eprint/411077
ISSN: 0074-7742
PURE UUID: 8b6f1790-37f6-4e2b-a724-4c0805b8eb21
ORCID for Melissa R Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 13 Jun 2017 16:33
Last modified: 27 Jan 2020 13:51

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Contributors

Author: Richard Eva
Author: Elske H P Franssen
Author: James W Fawcett

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