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GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study

GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study
GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study
Background
To meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.

Methods
From two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.

Results
Children and parents participated in 40% of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.

Conclusions
Despite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.

Trial registration Clinicaltrials.gov NCT02560415
Autism, Intervention, Computer gaming
1753-2000
11-17
Jouen, Anne‑Lise
fdbb39c1-821e-4ebb-8b56-9c72cf9a2c67
Narzisi, Antonio
5dc35240-975c-4d71-81e4-05a3a9af41d7
Xavier, Jean
dc385bb6-8615-496d-8567-100cc99c993f
Tilmont, Elodie
2144c4e0-e47d-4a41-ae05-c4bb29594f60
Bodeau, Nicolas
448c25f1-b6af-437c-ae35-93c2379918b5
Bono, Valentina
41b6a628-7777-4fa9-b658-2c27165fd29b
Ketem‑Premel, Nabila
2a084e22-5c63-42e5-8a32-0e5828db2a4a
Anzalone, Salvatore
2446d33c-0de4-429a-8cdf-a85e612ab801
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd
Chetouani, Mohamed
efc6fefe-0fd5-4642-b1f2-a47ef632a7ed
Muratori, Filippo
72a8f12f-671c-40e6-b3bc-219d497b6d76
Cohen, David
8bd9a96d-519b-463a-a69f-8883fd3acbdb
the MICHELANGELO Study Group
Jouen, Anne‑Lise
fdbb39c1-821e-4ebb-8b56-9c72cf9a2c67
Narzisi, Antonio
5dc35240-975c-4d71-81e4-05a3a9af41d7
Xavier, Jean
dc385bb6-8615-496d-8567-100cc99c993f
Tilmont, Elodie
2144c4e0-e47d-4a41-ae05-c4bb29594f60
Bodeau, Nicolas
448c25f1-b6af-437c-ae35-93c2379918b5
Bono, Valentina
41b6a628-7777-4fa9-b658-2c27165fd29b
Ketem‑Premel, Nabila
2a084e22-5c63-42e5-8a32-0e5828db2a4a
Anzalone, Salvatore
2446d33c-0de4-429a-8cdf-a85e612ab801
Maharatna, Koushik
93bef0a2-e011-4622-8c56-5447da4cd5dd
Chetouani, Mohamed
efc6fefe-0fd5-4642-b1f2-a47ef632a7ed
Muratori, Filippo
72a8f12f-671c-40e6-b3bc-219d497b6d76
Cohen, David
8bd9a96d-519b-463a-a69f-8883fd3acbdb

Jouen, Anne‑Lise, Narzisi, Antonio, Xavier, Jean, Tilmont, Elodie, Bodeau, Nicolas, Bono, Valentina, Ketem‑Premel, Nabila, Anzalone, Salvatore, Maharatna, Koushik, Chetouani, Mohamed, Muratori, Filippo and Cohen, David , the MICHELANGELO Study Group (2017) GOLIAH (Gaming Open Library for Intervention in Autism at Home): a 6-month single blind matched controlled exploratory study. Child and Adolescent Psychiatry and Mental Health, 11 (17), 11-17. (doi:10.1186/s13034-017-0154-7).

Record type: Article

Abstract

Background
To meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study.

Methods
From two specialized clinics, we included 14 children (age range 5–8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU). Participants from the experimental group received in addition to TAU four 30-min sessions with GOLIAH per week at home and one at hospital for 6 months. Statistics were performed using Linear Mixed Models.

Results
Children and parents participated in 40% of the planned sessions. They were able to use the 11 games, and participants trained with GOLIAH improved time to perform the task in most JA games and imitation scores in most imitation games. GOLIAH intervention did not affect Parental Stress Index scores. At end-point, we found in both groups a significant improvement for Autism Diagnostic Observation Schedule scores, Vineland socialization score, Parental Stress Index total score, and Child Behavior Checklist internalizing, externalizing and total problems. However, we found no significant change for by time × group interaction.

Conclusions
Despite the lack of superiority of TAU + GOLIAH versus TAU, the results are interesting both in terms of changes by using the gaming platform and lack of parental stress increase. A large randomized controlled trial with younger participants (who are the core target of ESDM model) is now discussed. This should be facilitated by computing GOLIAH for a web platform.

Trial registration Clinicaltrials.gov NCT02560415

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More information

Accepted/In Press date: 7 March 2017
e-pub ahead of print date: 22 March 2017
Keywords: Autism, Intervention, Computer gaming
Organisations: Finance, Electronic & Software Systems

Identifiers

Local EPrints ID: 411120
URI: https://eprints.soton.ac.uk/id/eprint/411120
ISSN: 1753-2000
PURE UUID: ca948bd2-647c-464c-9ff0-bb60ff1d5458

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Date deposited: 14 Jun 2017 16:31
Last modified: 16 Sep 2019 17:29

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