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Questionnaire-based reports of Quality of Survival and direct assessments of cognitive performance in children treated for medulloblastoma in the PNET 4 randomized controlled trial

Questionnaire-based reports of Quality of Survival and direct assessments of cognitive performance in children treated for medulloblastoma in the PNET 4 randomized controlled trial
Questionnaire-based reports of Quality of Survival and direct assessments of cognitive performance in children treated for medulloblastoma in the PNET 4 randomized controlled trial
Background: the relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied.

Methods: in the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard risk medulloblastoma from four European countries. QoS questionnaires, including self and/or parent reports of the Behavior Rating Inventory of Executive Function, the Health Utilities Index, the Strengths and Difficulties Questionnaire, and the Pediatric Quality of Life Inventory, were completed in 151survivors.Correlations of direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n=86).

Results: correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition index (parent-report) and working memory (r=.32) and between health status (self-report) and cognitive outcomes (.35-.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (.39-.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on two separate factors.

Conclusions: we hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions of the questionnaires, coupled with the relative absence of disease-specific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.
Medulloblastoma, outcome, intellectual ability, everyday executive functioning, Quality of Survival
1522-8517
iii148-iii149
Câmara-Costa, Hugo
65b5e0c2-f6bb-4bb5-aed2-aad428619544
Calaminus, Gabriele
5f85276d-ee2b-4336-8b0b-a94c7b69c7b2
Resch, Anika
2072eba5-f70c-488a-9a8d-94ab55ec422a
Kieffer, Virginie
040f3c1b-ab18-49bd-b25d-134c2bf55cf8
Lalande, Clémence
10392d88-06ab-4dd0-a879-00f51a0487e7
Poggi, Geraldina
b3f8f70b-6458-4682-a874-09c811539229
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
Bull, Kim
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Weiner, Andreas
6ecfef3f-0616-4a66-9120-8647c5d11995
von Hoff, Katja
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Grill, Jacques
27893adb-54ef-4eea-98dc-d94092ff1539
Doz, François
e481a57d-379f-4fda-adae-c37581e839f7
Rutkowski, Stefan
d77a8428-40b1-468a-9cfa-c85ad1b84ee3
Massimino, Maura
4fe9b9c6-1c49-43d0-b447-4ec24488d4d4
Kortmann, Rolf-Dieter
4feab9e1-94fd-4e7e-8304-aad3dbf473c5
Lannering, Birgitta
c2915eb4-d616-40cb-ba22-129805101ba5
Dellatolas, Georges
b6783dfd-3f84-4cc0-8588-4e55338f48e9
Chevignard, Mathilde
4bc19521-5c91-44cd-a4ca-20197d744e7a
Câmara-Costa, Hugo
65b5e0c2-f6bb-4bb5-aed2-aad428619544
Calaminus, Gabriele
5f85276d-ee2b-4336-8b0b-a94c7b69c7b2
Resch, Anika
2072eba5-f70c-488a-9a8d-94ab55ec422a
Kieffer, Virginie
040f3c1b-ab18-49bd-b25d-134c2bf55cf8
Lalande, Clémence
10392d88-06ab-4dd0-a879-00f51a0487e7
Poggi, Geraldina
b3f8f70b-6458-4682-a874-09c811539229
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
Bull, Kim
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Weiner, Andreas
6ecfef3f-0616-4a66-9120-8647c5d11995
von Hoff, Katja
1a7f04de-7bb8-452b-9761-4957ee9121d0
Grill, Jacques
27893adb-54ef-4eea-98dc-d94092ff1539
Doz, François
e481a57d-379f-4fda-adae-c37581e839f7
Rutkowski, Stefan
d77a8428-40b1-468a-9cfa-c85ad1b84ee3
Massimino, Maura
4fe9b9c6-1c49-43d0-b447-4ec24488d4d4
Kortmann, Rolf-Dieter
4feab9e1-94fd-4e7e-8304-aad3dbf473c5
Lannering, Birgitta
c2915eb4-d616-40cb-ba22-129805101ba5
Dellatolas, Georges
b6783dfd-3f84-4cc0-8588-4e55338f48e9
Chevignard, Mathilde
4bc19521-5c91-44cd-a4ca-20197d744e7a

Câmara-Costa, Hugo, Calaminus, Gabriele, Resch, Anika, Kieffer, Virginie, Lalande, Clémence, Poggi, Geraldina, Kennedy, Colin, Bull, Kim, Weiner, Andreas, von Hoff, Katja, Grill, Jacques, Doz, François, Rutkowski, Stefan, Massimino, Maura, Kortmann, Rolf-Dieter, Lannering, Birgitta, Dellatolas, Georges and Chevignard, Mathilde (2016) Questionnaire-based reports of Quality of Survival and direct assessments of cognitive performance in children treated for medulloblastoma in the PNET 4 randomized controlled trial. Neuro-Oncology, 18 (Supplement 3), iii148-iii149. (doi:10.1093/neuonc/now081.17).

Record type: Meeting abstract

Abstract

Background: the relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied.

Methods: in the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard risk medulloblastoma from four European countries. QoS questionnaires, including self and/or parent reports of the Behavior Rating Inventory of Executive Function, the Health Utilities Index, the Strengths and Difficulties Questionnaire, and the Pediatric Quality of Life Inventory, were completed in 151survivors.Correlations of direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n=86).

Results: correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition index (parent-report) and working memory (r=.32) and between health status (self-report) and cognitive outcomes (.35-.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (.39-.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on two separate factors.

Conclusions: we hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions of the questionnaires, coupled with the relative absence of disease-specific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.

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More information

Accepted/In Press date: 13 March 2016
e-pub ahead of print date: 30 May 2016
Published date: June 2016
Keywords: Medulloblastoma, outcome, intellectual ability, everyday executive functioning, Quality of Survival
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 411308
URI: https://eprints.soton.ac.uk/id/eprint/411308
ISSN: 1522-8517
PURE UUID: 536103f2-c8c2-49d2-bc17-08a27ac7eb98
ORCID for Kim Bull: ORCID iD orcid.org/0000-0002-5541-4556

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Date deposited: 17 Jun 2017 16:31
Last modified: 27 Apr 2019 00:36

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Contributors

Author: Hugo Câmara-Costa
Author: Gabriele Calaminus
Author: Anika Resch
Author: Virginie Kieffer
Author: Clémence Lalande
Author: Geraldina Poggi
Author: Colin Kennedy
Author: Kim Bull ORCID iD
Author: Andreas Weiner
Author: Katja von Hoff
Author: Jacques Grill
Author: François Doz
Author: Stefan Rutkowski
Author: Maura Massimino
Author: Rolf-Dieter Kortmann
Author: Birgitta Lannering
Author: Georges Dellatolas
Author: Mathilde Chevignard

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