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Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex

Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex
Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex

Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of PNNs. Here we show that the genetic attenuation of PNNs in adult brain Crtl1 knock-out mice enhances long-term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localized digestion of PNNs with chondroitinase ABC, an enzyme that degrades the chondroitin sulfate proteoglycan components of PNNs. The memory-enhancing effect of chondroitinase ABC treatment attenuated over time, suggesting that the regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that PNNs regulate both memory and experience-driven synaptic plasticity in adulthood.

0270-6474
7057-7065
Romberg, Carola
ab90bea6-9a6e-4df0-91a7-278c5ec6b46d
Yang, Sujeong
5a9f0a52-7263-4cf4-acab-ff40ad006782
Melani, Riccardo
c4732b57-9cfa-4b4c-98ba-83d2721d067e
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c
Horner, Alexa E.
10892bf6-a21d-4c32-8f45-4ad742b5770d
Spillantini, Maria G.
33bc74d0-8e18-47a9-850a-c65fcbe76ff7
Bussey, Timothy J.
472f7e69-6465-4d88-9301-8c6e26fcae72
Fawcett, James W.
4549730e-9f62-45b8-820b-8a9c98d1058b
Pizzorusso, Tommaso
fd491a61-8eab-4f78-82a3-4f26faab200e
Saksida, Lisa M.
5e48cbc8-2dc8-4de7-bfa3-6eb42fb1096a
Romberg, Carola
ab90bea6-9a6e-4df0-91a7-278c5ec6b46d
Yang, Sujeong
5a9f0a52-7263-4cf4-acab-ff40ad006782
Melani, Riccardo
c4732b57-9cfa-4b4c-98ba-83d2721d067e
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c
Horner, Alexa E.
10892bf6-a21d-4c32-8f45-4ad742b5770d
Spillantini, Maria G.
33bc74d0-8e18-47a9-850a-c65fcbe76ff7
Bussey, Timothy J.
472f7e69-6465-4d88-9301-8c6e26fcae72
Fawcett, James W.
4549730e-9f62-45b8-820b-8a9c98d1058b
Pizzorusso, Tommaso
fd491a61-8eab-4f78-82a3-4f26faab200e
Saksida, Lisa M.
5e48cbc8-2dc8-4de7-bfa3-6eb42fb1096a

Romberg, Carola, Yang, Sujeong, Melani, Riccardo, Andrews, Melissa R., Horner, Alexa E., Spillantini, Maria G., Bussey, Timothy J., Fawcett, James W., Pizzorusso, Tommaso and Saksida, Lisa M. (2013) Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex. Journal of Neuroscience, 33 (16), 7057-7065. (doi:10.1523/JNEUROSCI.6267-11.2013).

Record type: Article

Abstract

Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of PNNs. Here we show that the genetic attenuation of PNNs in adult brain Crtl1 knock-out mice enhances long-term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localized digestion of PNNs with chondroitinase ABC, an enzyme that degrades the chondroitin sulfate proteoglycan components of PNNs. The memory-enhancing effect of chondroitinase ABC treatment attenuated over time, suggesting that the regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that PNNs regulate both memory and experience-driven synaptic plasticity in adulthood.

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More information

Published date: 17 April 2013
Organisations: Biomedicine

Identifiers

Local EPrints ID: 411362
URI: https://eprints.soton.ac.uk/id/eprint/411362
ISSN: 0270-6474
PURE UUID: dc4f6fe0-72ce-4614-8f1a-fcb33869adc9
ORCID for Melissa R. Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 19 Jun 2017 16:31
Last modified: 10 Sep 2019 00:28

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