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Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury

Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury
Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury

Chondroitinase ABC (ChABC) in combination with rehabilitation has been shown to promote functional recovery in acute spinal cord injury. For clinical use, the optimal treatment window is concurrent with the beginning of rehabilitation, usually 2-4 weeks after injury. We show that ChABC is effective when given 4 weeks after injury combined with rehabilitation. After C4 dorsal spinal cord injury, rats received no treatment for 4 weeks. They then received either ChABC or penicillinase control treatment followed by hour-long daily rehabilitation specific for skilled paw reaching. Animals that received both ChABC and task-specific rehabilitation showed the greatest recovery in skilled paw reaching, approaching similar levels to animals that were treated at the time of injury. There was also a modest increase in skilled paw reaching ability in animals receiving task-specific rehabilitation alone. Animals treated with ChABC and task-specific rehabilitation also showed improvement in ladder and beam walking. ChABC increased sprouting of the corticospinal tract, and these sprouts had more vGlut1(+ve) presynaptic boutons than controls. Animals that received rehabilitation showed an increase in perineuronal net number and staining intensity. Our results indicate that ChABC treatment opens a window of opportunity in chronic spinal cord lesions, allowing rehabilitation to improve functional recovery.

0270-6474
9332-9344
Wang, Difei
9715478c-bba1-4418-ae99-1694f4bbfa08
Ichiyama, Ronaldo M
baec7ed5-e1a8-4c22-9ba9-ffea99c29aa6
Zhao, Rongrong
6efe06f7-51aa-4932-a5ea-c5857d6a9190
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c
Fawcett, James W.
4549730e-9f62-45b8-820b-8a9c98d1058b
Wang, Difei
9715478c-bba1-4418-ae99-1694f4bbfa08
Ichiyama, Ronaldo M
baec7ed5-e1a8-4c22-9ba9-ffea99c29aa6
Zhao, Rongrong
6efe06f7-51aa-4932-a5ea-c5857d6a9190
Andrews, Melissa R.
ae987a2f-878e-4ae3-a7a3-a7170712096c
Fawcett, James W.
4549730e-9f62-45b8-820b-8a9c98d1058b

Wang, Difei, Ichiyama, Ronaldo M, Zhao, Rongrong, Andrews, Melissa R. and Fawcett, James W. (2011) Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury. Journal of Neuroscience, 31 (25), 9332-9344. (doi:10.1523/JNEUROSCI.0983-11.2011).

Record type: Article

Abstract

Chondroitinase ABC (ChABC) in combination with rehabilitation has been shown to promote functional recovery in acute spinal cord injury. For clinical use, the optimal treatment window is concurrent with the beginning of rehabilitation, usually 2-4 weeks after injury. We show that ChABC is effective when given 4 weeks after injury combined with rehabilitation. After C4 dorsal spinal cord injury, rats received no treatment for 4 weeks. They then received either ChABC or penicillinase control treatment followed by hour-long daily rehabilitation specific for skilled paw reaching. Animals that received both ChABC and task-specific rehabilitation showed the greatest recovery in skilled paw reaching, approaching similar levels to animals that were treated at the time of injury. There was also a modest increase in skilled paw reaching ability in animals receiving task-specific rehabilitation alone. Animals treated with ChABC and task-specific rehabilitation also showed improvement in ladder and beam walking. ChABC increased sprouting of the corticospinal tract, and these sprouts had more vGlut1(+ve) presynaptic boutons than controls. Animals that received rehabilitation showed an increase in perineuronal net number and staining intensity. Our results indicate that ChABC treatment opens a window of opportunity in chronic spinal cord lesions, allowing rehabilitation to improve functional recovery.

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Published date: 22 June 2011
Organisations: Biomedicine

Identifiers

Local EPrints ID: 411365
URI: https://eprints.soton.ac.uk/id/eprint/411365
ISSN: 0270-6474
PURE UUID: eb14f3bc-e39d-4436-835a-c31aaed043b1
ORCID for Melissa R. Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 19 Jun 2017 16:31
Last modified: 05 Nov 2019 01:29

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Contributors

Author: Difei Wang
Author: Ronaldo M Ichiyama
Author: Rongrong Zhao
Author: James W. Fawcett

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