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The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis

The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis
The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis
The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.
0022-1767
6427-6432
Cotena, Alessia
8ede9e59-9fc7-405e-846c-5525f9a5fe74
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Platt, Nick
44ce8cb5-f0dc-4f54-bf2a-feecc48e8305
Cotena, Alessia
8ede9e59-9fc7-405e-846c-5525f9a5fe74
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Platt, Nick
44ce8cb5-f0dc-4f54-bf2a-feecc48e8305

Cotena, Alessia, Gordon, Siamon and Platt, Nick (2004) The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. Journal of Immunology, 173 (10), 6427-6432.

Record type: Article

Abstract

The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.

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Published date: 2004

Identifiers

Local EPrints ID: 41142
URI: https://eprints.soton.ac.uk/id/eprint/41142
ISSN: 0022-1767
PURE UUID: 72d4d23a-340a-46f9-94dd-373c0eabf4ab

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Date deposited: 21 Jul 2006
Last modified: 17 Jul 2017 15:32

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