The University of Southampton
University of Southampton Institutional Repository

The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis

Cotena, Alessia, Gordon, Siamon and Platt, Nick (2004) The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis Journal of Immunology, 173, (10), pp. 6427-6432.

Record type: Article

Abstract

The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude.

PDF Cotena_et_al_pdf.pdf - Other
Restricted to Registered users only
Download (208kB)

More information

Published date: 2004

Identifiers

Local EPrints ID: 41142
URI: http://eprints.soton.ac.uk/id/eprint/41142
ISSN: 0022-1767
PURE UUID: 72d4d23a-340a-46f9-94dd-373c0eabf4ab

Catalogue record

Date deposited: 21 Jul 2006
Last modified: 17 Jul 2017 15:32

Export record

Contributors

Author: Alessia Cotena
Author: Siamon Gordon
Author: Nick Platt

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×