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Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response

Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response
Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response
Dendritic cells (DC) function at the interface of innate and acquired immunity and are uniquely sensitive to specific stimuli. Pattern recognition receptors (PRR) on these cells are critically important because of their ability to recognise and initiate responses to conserved microbial-associated molecular signatures. With the exception of Toll-like receptors (TLR), we know relatively little about the specific distribution of other PRR amongst populations of DC. Here, we describe the expression of the murine class A macrophage scavenger receptor (SR-A) and show that it is restricted to specific subpopulations of bone marrow-derived and splenic DC. Importantly, we demonstrate that the receptor significantly alters the response of DC to endotoxin. In contrast to the activities of other PRR that have so far been examined, uniquely SR-A limits the maturation response; SR-A-/- cells display enhanced CD40 expression and TNF-alpha production. We discuss the potential contributions of SR-A to DC biology in the context of the known multiple activities of this receptor.
dendritic cells, knockout mice, scavenger receptor
0014-2980
950-960
Becker, Mike
9c7129ba-66e3-40cf-a365-9085e290fdec
Cotena, Alessia
8ede9e59-9fc7-405e-846c-5525f9a5fe74
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Platt, Nick
44ce8cb5-f0dc-4f54-bf2a-feecc48e8305
Becker, Mike
9c7129ba-66e3-40cf-a365-9085e290fdec
Cotena, Alessia
8ede9e59-9fc7-405e-846c-5525f9a5fe74
Gordon, Siamon
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Platt, Nick
44ce8cb5-f0dc-4f54-bf2a-feecc48e8305

Becker, Mike, Cotena, Alessia, Gordon, Siamon and Platt, Nick (2006) Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response. European Journal of Immunology, 36 (4), 950-960. (doi:10.1002/eji.200535660).

Record type: Article

Abstract

Dendritic cells (DC) function at the interface of innate and acquired immunity and are uniquely sensitive to specific stimuli. Pattern recognition receptors (PRR) on these cells are critically important because of their ability to recognise and initiate responses to conserved microbial-associated molecular signatures. With the exception of Toll-like receptors (TLR), we know relatively little about the specific distribution of other PRR amongst populations of DC. Here, we describe the expression of the murine class A macrophage scavenger receptor (SR-A) and show that it is restricted to specific subpopulations of bone marrow-derived and splenic DC. Importantly, we demonstrate that the receptor significantly alters the response of DC to endotoxin. In contrast to the activities of other PRR that have so far been examined, uniquely SR-A limits the maturation response; SR-A-/- cells display enhanced CD40 expression and TNF-alpha production. We discuss the potential contributions of SR-A to DC biology in the context of the known multiple activities of this receptor.

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Published date: April 2006
Additional Information: Innate immunity
Keywords: dendritic cells, knockout mice, scavenger receptor
Organisations: Biological Sciences

Identifiers

Local EPrints ID: 41144
URI: https://eprints.soton.ac.uk/id/eprint/41144
ISSN: 0014-2980
PURE UUID: 5169c961-9c1f-4492-98ff-49a7cb452a0d

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Date deposited: 21 Jul 2006
Last modified: 17 Jul 2017 15:32

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