The University of Southampton
University of Southampton Institutional Repository

Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia

Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia
Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia

We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/monocyte committed progenitor cells (CFU-c) by an agar method. Circulating erythroid burst-forming units (BFU-e) in CGL were increased above normal by a factor of about 180; CFU-c were increased by a factor of about 9000. Both BFU-e and CFU-c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU-c and BFU-e numbers. Circulating BFU-e and erythroid colony-forming cells (CFU-e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the 'clonal expansion' that characterizes CGL, but apparently to a lesser extent than are granulocyte/moonocyte progenitor cells.

Adolescent, Adult, Aged, Child, Colony-Forming Units Assay, Erythrocytes, Female, Granulocytes, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Leukocyte Count, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't
0007-1048
7-13
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Shiota, F
299651f1-a94a-4b2b-8778-4fabb9a94623
Th'ng, K H
e7b00688-308a-4d35-ad1d-931a409c9b1f
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Shiota, F
299651f1-a94a-4b2b-8778-4fabb9a94623
Th'ng, K H
e7b00688-308a-4d35-ad1d-931a409c9b1f
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2

Goldman, J M, Shiota, F, Th'ng, K H and Orchard, K H (1980) Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia. British Journal of Haematology, 46 (1), 7-13.

Record type: Article

Abstract

We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/monocyte committed progenitor cells (CFU-c) by an agar method. Circulating erythroid burst-forming units (BFU-e) in CGL were increased above normal by a factor of about 180; CFU-c were increased by a factor of about 9000. Both BFU-e and CFU-c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU-c and BFU-e numbers. Circulating BFU-e and erythroid colony-forming cells (CFU-e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the 'clonal expansion' that characterizes CGL, but apparently to a lesser extent than are granulocyte/moonocyte progenitor cells.

Full text not available from this repository.

More information

Published date: September 1980
Keywords: Adolescent, Adult, Aged, Child, Colony-Forming Units Assay, Erythrocytes, Female, Granulocytes, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Leukocyte Count, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 411591
URI: https://eprints.soton.ac.uk/id/eprint/411591
ISSN: 0007-1048
PURE UUID: 5dea74cb-a156-4f7e-b733-a931f26e2450
ORCID for K H Orchard: ORCID iD orcid.org/0000-0003-2276-3925

Catalogue record

Date deposited: 21 Jun 2017 16:31
Last modified: 14 Mar 2019 01:45

Export record

Contributors

Author: J M Goldman
Author: F Shiota
Author: K H Th'ng
Author: K H Orchard ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×