Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia
Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia
We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/monocyte committed progenitor cells (CFU-c) by an agar method. Circulating erythroid burst-forming units (BFU-e) in CGL were increased above normal by a factor of about 180; CFU-c were increased by a factor of about 9000. Both BFU-e and CFU-c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU-c and BFU-e numbers. Circulating BFU-e and erythroid colony-forming cells (CFU-e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the 'clonal expansion' that characterizes CGL, but apparently to a lesser extent than are granulocyte/moonocyte progenitor cells.
Adolescent, Adult, Aged, Child, Colony-Forming Units Assay, Erythrocytes, Female, Granulocytes, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Leukocyte Count, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't
7-13
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Shiota, F
299651f1-a94a-4b2b-8778-4fabb9a94623
Th'ng, K H
e7b00688-308a-4d35-ad1d-931a409c9b1f
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2
September 1980
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Shiota, F
299651f1-a94a-4b2b-8778-4fabb9a94623
Th'ng, K H
e7b00688-308a-4d35-ad1d-931a409c9b1f
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2
Goldman, J M, Shiota, F, Th'ng, K H and Orchard, K H
(1980)
Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia.
British Journal of Haematology, 46 (1), .
Abstract
We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/monocyte committed progenitor cells (CFU-c) by an agar method. Circulating erythroid burst-forming units (BFU-e) in CGL were increased above normal by a factor of about 180; CFU-c were increased by a factor of about 9000. Both BFU-e and CFU-c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU-c and BFU-e numbers. Circulating BFU-e and erythroid colony-forming cells (CFU-e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the 'clonal expansion' that characterizes CGL, but apparently to a lesser extent than are granulocyte/moonocyte progenitor cells.
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Published date: September 1980
Keywords:
Adolescent, Adult, Aged, Child, Colony-Forming Units Assay, Erythrocytes, Female, Granulocytes, Hematopoietic Stem Cells, Humans, Leukemia, Myeloid, Leukocyte Count, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 411591
URI: http://eprints.soton.ac.uk/id/eprint/411591
ISSN: 0007-1048
PURE UUID: 5dea74cb-a156-4f7e-b733-a931f26e2450
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Date deposited: 21 Jun 2017 16:31
Last modified: 20 Jan 2024 02:40
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Author:
J M Goldman
Author:
F Shiota
Author:
K H Th'ng
Author:
K H Orchard
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