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Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1

Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1
Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1

The erythroid transcription factor erythroid factor-1 (EF1) plays a critical role in the transcription of erythroid-specific genes. Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of non-erythroid cell types. This is the first report of an EF1-like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells.

Animals, Binding, Competitive, Cell Line, Cell Nucleus, DNA, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Erythroid-Specific DNA-Binding Factors, HeLa Cells, Humans, Leukemia, Erythroblastic, Acute, Mice, T-Lymphocytes, Teratoma, Transcription Factors, Tumor Cells, Cultured, Journal Article, Research Support, Non-U.S. Gov't
0264-6021
543-5
Perkins, N D
cd0fd1b8-1a84-45d3-aef1-6cee63249309
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2
Collins, M L
39c341a9-3dab-40e3-9d5a-b77cdb360ffd
Latchman, D S
917ce95a-ac18-47da-881d-4fece00ae530
Goodwin, G H
92787fdd-1a5f-4e45-bbbe-c31b720b8d89
Perkins, N D
cd0fd1b8-1a84-45d3-aef1-6cee63249309
Orchard, K H
794654ab-d6cc-488a-ac11-c9217433c7a2
Collins, M L
39c341a9-3dab-40e3-9d5a-b77cdb360ffd
Latchman, D S
917ce95a-ac18-47da-881d-4fece00ae530
Goodwin, G H
92787fdd-1a5f-4e45-bbbe-c31b720b8d89

Perkins, N D, Orchard, K H, Collins, M L, Latchman, D S and Goodwin, G H (1990) Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1. Biochemical Journal, 269 (2), 543-5.

Record type: Article

Abstract

The erythroid transcription factor erythroid factor-1 (EF1) plays a critical role in the transcription of erythroid-specific genes. Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of non-erythroid cell types. This is the first report of an EF1-like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells.

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More information

Published date: 15 July 1990
Keywords: Animals, Binding, Competitive, Cell Line, Cell Nucleus, DNA, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Erythroid-Specific DNA-Binding Factors, HeLa Cells, Humans, Leukemia, Erythroblastic, Acute, Mice, T-Lymphocytes, Teratoma, Transcription Factors, Tumor Cells, Cultured, Journal Article, Research Support, Non-U.S. Gov't
Organisations: Cancer Sciences, Electronics & Computer Science

Identifiers

Local EPrints ID: 411595
URI: https://eprints.soton.ac.uk/id/eprint/411595
ISSN: 0264-6021
PURE UUID: eb3a3f70-e0cb-41fa-b5f7-9ebdbba9a955
ORCID for K H Orchard: ORCID iD orcid.org/0000-0003-2276-3925

Catalogue record

Date deposited: 21 Jun 2017 16:31
Last modified: 14 Mar 2019 01:45

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