Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant
Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant
We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
Acute Disease, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Transplantation, Chromosome Breakage, Chromosome Inversion, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 8, Erythrocytes, Abnormal, Female, Humans, Infant, Karyotyping, Leukemia, Myeloid, Phagocytosis, Case Reports, Journal Article
561-3
Coulthard, S
326c3f71-f626-4314-b3b5-c5a54889f576
Chase, A
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Orchard, K
794654ab-d6cc-488a-ac11-c9217433c7a2
Watmore, A
95ae2283-7a3c-43b1-a03c-c88acc182399
Vora, A
00eb2d49-1597-4dc2-adcb-24c32c605abc
Goldman, J M
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Swirsky, D M
9f66861a-6abe-48f0-bcac-a379da38a9e1
March 1998
Coulthard, S
326c3f71-f626-4314-b3b5-c5a54889f576
Chase, A
a40a09c2-3073-4655-ba0b-a802e34914b5
Orchard, K
794654ab-d6cc-488a-ac11-c9217433c7a2
Watmore, A
95ae2283-7a3c-43b1-a03c-c88acc182399
Vora, A
00eb2d49-1597-4dc2-adcb-24c32c605abc
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Swirsky, D M
9f66861a-6abe-48f0-bcac-a379da38a9e1
Coulthard, S, Chase, A, Orchard, K, Watmore, A, Vora, A, Goldman, J M and Swirsky, D M
(1998)
Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant.
British Journal of Haematology, 100 (3), .
Abstract
We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
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More information
Published date: March 1998
Keywords:
Acute Disease, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Transplantation, Chromosome Breakage, Chromosome Inversion, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 8, Erythrocytes, Abnormal, Female, Humans, Infant, Karyotyping, Leukemia, Myeloid, Phagocytosis, Case Reports, Journal Article
Organisations:
Cancer Sciences, Human Development & Health
Identifiers
Local EPrints ID: 411599
URI: http://eprints.soton.ac.uk/id/eprint/411599
ISSN: 0007-1048
PURE UUID: 7dd6dc2d-8fad-4d18-abb9-9cab90951865
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Date deposited: 21 Jun 2017 16:31
Last modified: 20 Jan 2024 02:40
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Contributors
Author:
S Coulthard
Author:
K Orchard
Author:
A Watmore
Author:
A Vora
Author:
J M Goldman
Author:
D M Swirsky
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