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Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant

Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant
Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant

We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.

Acute Disease, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Transplantation, Chromosome Breakage, Chromosome Inversion, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 8, Erythrocytes, Abnormal, Female, Humans, Infant, Karyotyping, Leukemia, Myeloid, Phagocytosis, Case Reports, Journal Article
0007-1048
561-3
Coulthard, S
326c3f71-f626-4314-b3b5-c5a54889f576
Chase, A
a40a09c2-3073-4655-ba0b-a802e34914b5
Orchard, K
794654ab-d6cc-488a-ac11-c9217433c7a2
Watmore, A
95ae2283-7a3c-43b1-a03c-c88acc182399
Vora, A
00eb2d49-1597-4dc2-adcb-24c32c605abc
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Swirsky, D M
9f66861a-6abe-48f0-bcac-a379da38a9e1
Coulthard, S
326c3f71-f626-4314-b3b5-c5a54889f576
Chase, A
a40a09c2-3073-4655-ba0b-a802e34914b5
Orchard, K
794654ab-d6cc-488a-ac11-c9217433c7a2
Watmore, A
95ae2283-7a3c-43b1-a03c-c88acc182399
Vora, A
00eb2d49-1597-4dc2-adcb-24c32c605abc
Goldman, J M
2c27a1b3-c445-4593-a6b5-2e6e749fa1cb
Swirsky, D M
9f66861a-6abe-48f0-bcac-a379da38a9e1

Coulthard, S, Chase, A, Orchard, K, Watmore, A, Vora, A, Goldman, J M and Swirsky, D M (1998) Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant. British Journal of Haematology, 100 (3), 561-3.

Record type: Article

Abstract

We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.

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More information

Published date: March 1998
Keywords: Acute Disease, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Transplantation, Chromosome Breakage, Chromosome Inversion, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 8, Erythrocytes, Abnormal, Female, Humans, Infant, Karyotyping, Leukemia, Myeloid, Phagocytosis, Case Reports, Journal Article
Organisations: Cancer Sciences, Human Development & Health

Identifiers

Local EPrints ID: 411599
URI: https://eprints.soton.ac.uk/id/eprint/411599
ISSN: 0007-1048
PURE UUID: 7dd6dc2d-8fad-4d18-abb9-9cab90951865
ORCID for K Orchard: ORCID iD orcid.org/0000-0003-2276-3925

Catalogue record

Date deposited: 21 Jun 2017 16:31
Last modified: 14 Mar 2019 01:45

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Contributors

Author: S Coulthard
Author: A Chase
Author: K Orchard ORCID iD
Author: A Watmore
Author: A Vora
Author: J M Goldman
Author: D M Swirsky

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