Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication
Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication
We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of the mumps viral RNA isolated from neural tissue indicated that the infection was acquired at the time of a mumps outbreak in England and Wales that occurred between 2004 and 2006. This case highlights the importance of considering mumps in the differential diagnosis of central nervous system infection in highly immunosuppressed patients.
Adult, Encephalomyelitis, Fatal Outcome, Hematopoietic Stem Cell Transplantation, Humans, Male, Mumps, Mumps virus, Severe Combined Immunodeficiency, Young Adult, Case Reports, Journal Article
165-8
Eyre, Toby A
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Pelosi, Emanuela
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McQuaid, Stephen
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Richardson, Deborah
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Newman, Joan
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Hill, Kate
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Veys, Paul
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Davies, Graham
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Orchard, Kim H
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June 2013
Eyre, Toby A
77f24ed8-4e94-4fa2-a29a-1a700f87ecdb
Pelosi, Emanuela
d07026a0-0508-47d1-92de-b99c22aa29da
McQuaid, Stephen
5b770345-9c77-4a61-bc87-4482d21799c6
Richardson, Deborah
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Newman, Joan
67ca8296-d71d-430c-afa9-635fdd1dd4ad
Hill, Kate
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Veys, Paul
8d2df188-ba92-4a28-bc1b-b6319ead3d7b
Davies, Graham
25b72164-1bcb-4a6a-baf6-0b29ee4a840e
Orchard, Kim H
794654ab-d6cc-488a-ac11-c9217433c7a2
Eyre, Toby A, Pelosi, Emanuela, McQuaid, Stephen, Richardson, Deborah, Newman, Joan, Hill, Kate, Veys, Paul, Davies, Graham and Orchard, Kim H
(2013)
Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication.
Journal of Clinical Virology, 57 (2), .
(doi:10.1016/j.jcv.2013.02.003).
Abstract
We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of the mumps viral RNA isolated from neural tissue indicated that the infection was acquired at the time of a mumps outbreak in England and Wales that occurred between 2004 and 2006. This case highlights the importance of considering mumps in the differential diagnosis of central nervous system infection in highly immunosuppressed patients.
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Published date: June 2013
Keywords:
Adult, Encephalomyelitis, Fatal Outcome, Hematopoietic Stem Cell Transplantation, Humans, Male, Mumps, Mumps virus, Severe Combined Immunodeficiency, Young Adult, Case Reports, Journal Article
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 411604
URI: http://eprints.soton.ac.uk/id/eprint/411604
ISSN: 1386-6532
PURE UUID: bb8498bb-b2ac-4211-842c-bfb11f59f992
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Date deposited: 21 Jun 2017 16:31
Last modified: 16 Mar 2024 03:26
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Author:
Toby A Eyre
Author:
Emanuela Pelosi
Author:
Stephen McQuaid
Author:
Deborah Richardson
Author:
Joan Newman
Author:
Kate Hill
Author:
Paul Veys
Author:
Graham Davies
Author:
Kim H Orchard
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