Lifecourse social position and D-Dimer: Findings from the 1958 British Birth Cohort
Lifecourse social position and D-Dimer: Findings from the 1958 British Birth Cohort
The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.
Tabassum, Faiza
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Kumari, Meena
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Rumley, Ann
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Power, Chris
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Strachan, David P.
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Lowe, Gordon
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8 May 2014
Tabassum, Faiza
a4bcd2d6-c576-4e85-8ba4-c3b4bb1ade08
Kumari, Meena
fc42bd66-3f7c-4f72-8f7b-d9cb40900b3d
Rumley, Ann
3b4a7cb5-6293-44bf-8e32-76e284e88a1a
Power, Chris
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Strachan, David P.
76ddbacc-b6cb-48db-8ab6-77f799c8d1c8
Lowe, Gordon
ffe6539c-6998-45d2-b766-c70cacb7c08f
Tabassum, Faiza, Kumari, Meena, Rumley, Ann, Power, Chris, Strachan, David P. and Lowe, Gordon
(2014)
Lifecourse social position and D-Dimer: Findings from the 1958 British Birth Cohort.
PLoS ONE, 9 (5), [e93277].
(doi:10.1371/journal.pone.0093277).
Abstract
The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.
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Accepted/In Press date: 4 March 2014
Published date: 8 May 2014
Organisations:
Social Sciences
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Local EPrints ID: 412031
URI: http://eprints.soton.ac.uk/id/eprint/412031
ISSN: 1932-6203
PURE UUID: e648e34e-c748-4164-91be-9d829ad59beb
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Date deposited: 05 Jul 2017 16:31
Last modified: 08 Jan 2022 13:12
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Author:
Meena Kumari
Author:
Ann Rumley
Author:
Chris Power
Author:
David P. Strachan
Author:
Gordon Lowe
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