Boundary-induced orientation of dynamic filament networks and vesicle agglomerations
Boundary-induced orientation of dynamic filament networks and vesicle agglomerations
We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in
the absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization
dynamics and is independent of filament interactions and explicit regulation. It can be understood by an analogy
to electrostatics and appears to be induced by the confining boundaries; for periodic boundary conditions, no
orientational bias emerges. Including active transport of particles, the model reproduces experimental observations
of vesicle accumulations in transected axons.
060902-1
Greulich, Philip
65da32ad-a73a-435a-86e0-e171437430a9
Santen, Ludger
0ba4b37c-977a-427e-abf7-b2ad64935767
27 December 2011
Greulich, Philip
65da32ad-a73a-435a-86e0-e171437430a9
Santen, Ludger
0ba4b37c-977a-427e-abf7-b2ad64935767
Greulich, Philip and Santen, Ludger
(2011)
Boundary-induced orientation of dynamic filament networks and vesicle agglomerations.
Physical Review E, 84, , [060902].
Abstract
We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in
the absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization
dynamics and is independent of filament interactions and explicit regulation. It can be understood by an analogy
to electrostatics and appears to be induced by the confining boundaries; for periodic boundary conditions, no
orientational bias emerges. Including active transport of particles, the model reproduces experimental observations
of vesicle accumulations in transected axons.
Text
Greulich Santen Phys Rev E 2011
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Published date: 27 December 2011
Organisations:
Applied Mathematics
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Local EPrints ID: 412059
URI: http://eprints.soton.ac.uk/id/eprint/412059
ISSN: 1063-651X
PURE UUID: ab6bacb3-1034-4895-9b27-33f604896797
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Date deposited: 05 Jul 2017 16:31
Last modified: 16 Mar 2024 04:17
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Author:
Ludger Santen
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