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Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems

Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems
Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems
The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications.
Harris, Nicholas
237cfdbd-86e4-4025-869c-c85136f14dfd
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385
Harris, Nicholas
237cfdbd-86e4-4025-869c-c85136f14dfd
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385

Harris, Nicholas and Lewis, Adam P. (2017) Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems. Eurosensors XXXI, Paris, France. (Submitted)

Record type: Conference or Workshop Item (Poster)

Abstract

The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications.

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More information

Submitted date: 2017
Venue - Dates: Eurosensors XXXI, Paris, France, 2017-09-03

Identifiers

Local EPrints ID: 412098
URI: http://eprints.soton.ac.uk/id/eprint/412098
PURE UUID: f3c7e4da-69cc-4eca-8340-7eb3dba80008
ORCID for Nicholas Harris: ORCID iD orcid.org/0000-0003-4122-2219

Catalogue record

Date deposited: 11 Jul 2017 09:43
Last modified: 14 Mar 2019 01:53

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