A two-directional synthesis of (+)-β-isosparteine
A two-directional synthesis of (+)-β-isosparteine
A two-directional synthesis of (+)-β-isosparteine is described in five steps from glutaric acid, where the entire carbon and nitrogen backbone of the alkaloid, possessing the requisite relative and absolute stereochemistry at its four stereogenic centers, is assembled using a double imino-aldol reaction.
3502-3504
Al-Saffar, Firas, Mohammed
3a365813-cd6a-4009-86f8-d872a5cabdf0
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Al-Saffar, Firas, Mohammed
3a365813-cd6a-4009-86f8-d872a5cabdf0
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Al-Saffar, Firas, Mohammed and Brown, Richard C.D.
(2017)
A two-directional synthesis of (+)-β-isosparteine.
Organic Letters, 19 (13), .
(doi:10.1021/acs.orglett.7b01475).
Abstract
A two-directional synthesis of (+)-β-isosparteine is described in five steps from glutaric acid, where the entire carbon and nitrogen backbone of the alkaloid, possessing the requisite relative and absolute stereochemistry at its four stereogenic centers, is assembled using a double imino-aldol reaction.
Text
ol-2017-01475n
- Accepted Manuscript
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Accepted/In Press date: 9 June 2017
e-pub ahead of print date: 13 June 2017
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Local EPrints ID: 412136
URI: http://eprints.soton.ac.uk/id/eprint/412136
ISSN: 1523-7060
PURE UUID: c9a58328-c921-422f-b8fa-851f61cfbc24
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Date deposited: 11 Jul 2017 16:31
Last modified: 16 Mar 2024 05:31
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Author:
Firas, Mohammed Al-Saffar
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