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Economic evaluations and diagnostic testing: An illustrative case study approach

Economic evaluations and diagnostic testing: An illustrative case study approach
Economic evaluations and diagnostic testing: An illustrative case study approach

Objective: The aim of this study was to present a clear process of synthesizing test accuracy data when conducting economic evaluations of diagnostic tests for health technology assessment (HTA) assessors and health economists. Methods: We appraised the methods advocated for using diagnostic test accuracy data in economic evaluations. We used a case study of fetal anemia in which data from a screening test are used in combination with a confirmatory test. Results: We developed a step-by-step guide and consider two scenarios: when data on test accuracy from several studies are based on (i) the same test threshold for positivity and (ii) different test thresholds. Conclusions: We conclude that each approach has its strengths and limitations. We show that the optimal operating point of the test should be identified to determine the true cost-effectiveness of the test. We advocate that these issues require a multidisciplinary team of health economists, decision modelers and statisticians.

Diagnostic tests, Economic evaluation, ROC curve, Sensitivity and specificity
0266-4623
53-60
Sanghera, Sabina
e165b79f-0c51-4ed5-9c0d-921f738617d6
Orlando, Rosa
cc20c869-ca7f-4518-ad2d-0fa56caa3c86
Roberts, Tracy
6964df84-5fec-42a5-aa2f-fb207b6fb2dc
Sanghera, Sabina
e165b79f-0c51-4ed5-9c0d-921f738617d6
Orlando, Rosa
cc20c869-ca7f-4518-ad2d-0fa56caa3c86
Roberts, Tracy
6964df84-5fec-42a5-aa2f-fb207b6fb2dc

Sanghera, Sabina, Orlando, Rosa and Roberts, Tracy (2013) Economic evaluations and diagnostic testing: An illustrative case study approach. International Journal of Technology Assessment in Health Care, 29 (1), 53-60. (doi:10.1017/S0266462312000682).

Record type: Article

Abstract

Objective: The aim of this study was to present a clear process of synthesizing test accuracy data when conducting economic evaluations of diagnostic tests for health technology assessment (HTA) assessors and health economists. Methods: We appraised the methods advocated for using diagnostic test accuracy data in economic evaluations. We used a case study of fetal anemia in which data from a screening test are used in combination with a confirmatory test. Results: We developed a step-by-step guide and consider two scenarios: when data on test accuracy from several studies are based on (i) the same test threshold for positivity and (ii) different test thresholds. Conclusions: We conclude that each approach has its strengths and limitations. We show that the optimal operating point of the test should be identified to determine the true cost-effectiveness of the test. We advocate that these issues require a multidisciplinary team of health economists, decision modelers and statisticians.

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More information

Published date: January 2013
Keywords: Diagnostic tests, Economic evaluation, ROC curve, Sensitivity and specificity

Identifiers

Local EPrints ID: 412535
URI: http://eprints.soton.ac.uk/id/eprint/412535
ISSN: 0266-4623
PURE UUID: fbde83b0-f489-4b71-babe-80c3de7309f6
ORCID for Rosa Orlando: ORCID iD orcid.org/0000-0002-7097-5431

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Date deposited: 20 Jul 2017 16:30
Last modified: 15 Mar 2024 15:20

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Contributors

Author: Sabina Sanghera
Author: Rosa Orlando ORCID iD
Author: Tracy Roberts

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