Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort

Abstract

Eosinophilic inflammation in COPD predicts response to treatment especially corticosteroids. We studied the nature of eosinophilic inflammation in COPD prospectively to examine the stability of this phenotype and its dynamics across exacerbations and its associations with clinical phenotype, exacerbations and infection.127 patients aged 40–85 with moderate-severe COPD underwent repeated blood and sputum sampling at stable visits and within 72 h of exacerbation for one year. Blood eosinophils ≥2% was prevalent at baseline and predicted both predominantly raised stable state eosinophils across the year (AUC 0.841, 95%CI 0.755; 0.928), and increased risk of eosinophilic inflammation at exacerbation (OR 9.16 p<0.001). Eosinophils≥2% at exacerbation and eosinophil predominance at stable visits were associated with a lower risk of bacterial presence at exacerbation (OR 0.49, p=0.049 and OR 0.25, p=0.065 respectively). Bacterial infection at exacerbation was highly seasonal (Winter vs Summer OR 4.74, p=0.011) in predominantly eosinophilic patients.Eosinophilic inflammation is a common and stable phenotype in COPD. Blood eosinophil counts in the stable state can predict the nature of inflammation at future exacerbations which when combined with an understanding of seasonal variation provides the basis for the development of new treatment paradigms for this important condition

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Identifiers

ORCID for Karl J Staples: orcid.org/0000-0003-3844-6457

ORCID for Stuart C Clarke: orcid.org/0000-0002-7009-1548

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