Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis
Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis
Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) after subarachnoid haemorrhage (SAH), but not long–term outcome (Glasgow Outcome score and modified Rankin Scale between one and three months). Closer examination of the heterozygous group revealed that the short-term outcome of Hp2-1 individuals clustered with that of Hp1-1 and not Hp2-2, suggesting that the presence of one Hp1 allele was sufficient to confer protection. Since the presence of the Hp dimer is the only common feature between Hp1-1 and Hp2-1 individuals, the absence of this Hp moiety is most likely to underlie vasospasm in Hp2-2 individuals. These results have implications for prognosis after SAH and will inform further research into Hp-based mechanism of action and treatment.
Gaastra, Benjamin
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Glazier, James
cd25b20a-e5b6-4697-89cc-6ee8930b8e6d
Bulters, Diederik
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Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
2017
Gaastra, Benjamin
c7b7f371-706b-4d59-9150-94e8f254e205
Glazier, James
cd25b20a-e5b6-4697-89cc-6ee8930b8e6d
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Gaastra, Benjamin, Glazier, James, Bulters, Diederik and Galea, Ian
(2017)
Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis.
Oxidative Medicine and Cellular Longevity, 2017, [6747940].
(doi:10.1155/2017/6747940).
Abstract
Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) after subarachnoid haemorrhage (SAH), but not long–term outcome (Glasgow Outcome score and modified Rankin Scale between one and three months). Closer examination of the heterozygous group revealed that the short-term outcome of Hp2-1 individuals clustered with that of Hp1-1 and not Hp2-2, suggesting that the presence of one Hp1 allele was sufficient to confer protection. Since the presence of the Hp dimer is the only common feature between Hp1-1 and Hp2-1 individuals, the absence of this Hp moiety is most likely to underlie vasospasm in Hp2-2 individuals. These results have implications for prognosis after SAH and will inform further research into Hp-based mechanism of action and treatment.
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6747940
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6747940
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Accepted/In Press date: 25 July 2017
e-pub ahead of print date: 26 September 2017
Published date: 2017
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Local EPrints ID: 412759
URI: http://eprints.soton.ac.uk/id/eprint/412759
ISSN: 1942-0900
PURE UUID: b1089c59-20a3-4be8-b4b1-d2fca871be07
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Date deposited: 01 Aug 2017 16:31
Last modified: 16 Mar 2024 05:35
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Author:
James Glazier
Author:
Diederik Bulters
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