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Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis

Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis
Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis
Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) after subarachnoid haemorrhage (SAH), but not long–term outcome (Glasgow Outcome score and modified Rankin Scale between one and three months). Closer examination of the heterozygous group revealed that the short-term outcome of Hp2-1 individuals clustered with that of Hp1-1 and not Hp2-2, suggesting that the presence of one Hp1 allele was sufficient to confer protection. Since the presence of the Hp dimer is the only common feature between Hp1-1 and Hp2-1 individuals, the absence of this Hp moiety is most likely to underlie vasospasm in Hp2-2 individuals. These results have implications for prognosis after SAH and will inform further research into Hp-based mechanism of action and treatment.
1942-0900
1-10
Gaastra, Benjamin
f48eac25-66e4-4e0b-8325-d4e4b9558d8f
Glazier, James
cd25b20a-e5b6-4697-89cc-6ee8930b8e6d
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Gaastra, Benjamin
f48eac25-66e4-4e0b-8325-d4e4b9558d8f
Glazier, James
cd25b20a-e5b6-4697-89cc-6ee8930b8e6d
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Gaastra, Benjamin, Glazier, James, Bulters, Diederik and Galea, Ian (2017) Haptoglobin genotype and outcome after subarachnoid haemorrhage: new insights from a meta-analysis. Oxidative Medicine and Cellular Longevity, 2017 (6747940), 1-10. (doi:10.1155/2017/6747940).

Record type: Article

Abstract

Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) after subarachnoid haemorrhage (SAH), but not long–term outcome (Glasgow Outcome score and modified Rankin Scale between one and three months). Closer examination of the heterozygous group revealed that the short-term outcome of Hp2-1 individuals clustered with that of Hp1-1 and not Hp2-2, suggesting that the presence of one Hp1 allele was sufficient to confer protection. Since the presence of the Hp dimer is the only common feature between Hp1-1 and Hp2-1 individuals, the absence of this Hp moiety is most likely to underlie vasospasm in Hp2-2 individuals. These results have implications for prognosis after SAH and will inform further research into Hp-based mechanism of action and treatment.

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Accepted/In Press date: 25 July 2017
e-pub ahead of print date: 26 September 2017
Published date: 2017

Identifiers

Local EPrints ID: 412759
URI: https://eprints.soton.ac.uk/id/eprint/412759
ISSN: 1942-0900
PURE UUID: b1089c59-20a3-4be8-b4b1-d2fca871be07
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 01 Aug 2017 16:31
Last modified: 10 Dec 2019 05:54

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