Targeting the bone marrow: applications in stem cell transplantation
Targeting the bone marrow: applications in stem cell transplantation
Therapeutic doses of radiation can be selectively directed to the bone marrow either directly using vectors that bind to myeloid and/or lymphoid specific antigens or indirectly by targeting bone matrix. The combination of an accessible target tissue and relatively radiation sensitive malignant cells favours the use of targeted radiotherapy in the treatment of haematopoietic malignancies. Dose escalation of targeted radiation can increase tumour cell destruction and has led to the use of myelosuppressive and possibly myeloablative doses of targeted radiation. A natural development has been the use of targeted radiation in conditioning prior to haematopoietic stem cell transplantation (HSCT). Several groups are actively exploring the use of targeted radiotherapy in the context of HSCT as treatment for haematological malignancies. Although no randomised trials using targeted radiotherapy in HSCT have been published, phase I and II trials have shown very encouraging results stimulating further clinical research in this field. After more than a decade of translational research the optimal combination of therapeutic radioisotope and vector has not been determined. This review summarises the clinical experience of targeted radiotherapy in HSCT and discusses the problems that still need to be solved to maximise the potential of this new treatment modality in HSCT.
Animals, Bone Marrow, Clinical Trials as Topic, Drug Delivery Systems, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Radioimmunotherapy, Radiotherapy, Adjuvant, Treatment Outcome, Journal Article, Review
267-278
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Cooper, Margaret
e562892a-480f-44de-88dd-cf6db92866a0
December 2004
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Cooper, Margaret
e562892a-480f-44de-88dd-cf6db92866a0
Orchard, K. and Cooper, Margaret
(2004)
Targeting the bone marrow: applications in stem cell transplantation.
The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 48 (4), .
Abstract
Therapeutic doses of radiation can be selectively directed to the bone marrow either directly using vectors that bind to myeloid and/or lymphoid specific antigens or indirectly by targeting bone matrix. The combination of an accessible target tissue and relatively radiation sensitive malignant cells favours the use of targeted radiotherapy in the treatment of haematopoietic malignancies. Dose escalation of targeted radiation can increase tumour cell destruction and has led to the use of myelosuppressive and possibly myeloablative doses of targeted radiation. A natural development has been the use of targeted radiation in conditioning prior to haematopoietic stem cell transplantation (HSCT). Several groups are actively exploring the use of targeted radiotherapy in the context of HSCT as treatment for haematological malignancies. Although no randomised trials using targeted radiotherapy in HSCT have been published, phase I and II trials have shown very encouraging results stimulating further clinical research in this field. After more than a decade of translational research the optimal combination of therapeutic radioisotope and vector has not been determined. This review summarises the clinical experience of targeted radiotherapy in HSCT and discusses the problems that still need to be solved to maximise the potential of this new treatment modality in HSCT.
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Published date: December 2004
Keywords:
Animals, Bone Marrow, Clinical Trials as Topic, Drug Delivery Systems, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Radioimmunotherapy, Radiotherapy, Adjuvant, Treatment Outcome, Journal Article, Review
Identifiers
Local EPrints ID: 412841
URI: http://eprints.soton.ac.uk/id/eprint/412841
ISSN: 1824-4785
PURE UUID: f3a99cae-865b-439b-b821-ae8f509f5c51
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Date deposited: 02 Aug 2017 16:30
Last modified: 27 Feb 2024 02:40
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Author:
K. Orchard
Author:
Margaret Cooper
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