The University of Southampton
University of Southampton Institutional Repository

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study
The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study
BACKGROUND: Vitamin D insufficiency (defined as <75 nmol/l) is widespread amongst pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders including asthma and eczema are on the rise amongst children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood. SUBJECTS AND METHODS: Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks’ gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints (SCOPE) cohort study. The offspring of 1208 mothers were followed up at age 5–6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedence) and history of asthma and eczema. Multivariable analysis controlled for maternal BMI, age and sex of the child and season of serum sampling. RESULTS: Complete data were available for 922 mother-child pairs. Each 10 nmol/l increase in maternal 25-hydroxyvitamin D concentration at 15 weeks’ gestation was associated with a decrease in offspring PBF of 0.2% (95% CI 0.04–0.36% P=0.01) after adjustment for confounders, but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol/l P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol/l P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol/l P=0.5). CONCLUSIONS: The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials.
0307-0565
1755–1760
Boyle, V.T.
c8a0a0f8-575d-443d-830c-f51aced60e76
Thorstensen, E.B.
80bb40ab-5146-4f0c-976d-188729f87df8
Thompson, J.M.D.
91a07542-c44c-40bb-ba5c-f88f73d502cd
Mitchell, E.A.
479ddddc-b1ab-4cba-a4f5-17e110772d28
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Poston, L.
86dde088-a1f1-44c1-a6e5-26f1591f6323
Wall, C.R.
fa8a9d65-ce55-4165-b3f9-52fcca87213b
Murphy, R.
e98bfddf-d951-4964-a173-d82afedc02a6
Cutfield, Wayne
a01589bd-5b82-49fa-89e1-137e6f59e24d
Kenealy, T.
f88dc737-bdd7-40c4-af80-d3a882cc203e
Kenny, L.C.
116b46cf-fe4f-46ab-a445-c7564b0e7f23
Baker, Philip N.
e1cd37f8-ad89-4ec9-852a-0de07468abab
Boyle, V.T.
c8a0a0f8-575d-443d-830c-f51aced60e76
Thorstensen, E.B.
80bb40ab-5146-4f0c-976d-188729f87df8
Thompson, J.M.D.
91a07542-c44c-40bb-ba5c-f88f73d502cd
Mitchell, E.A.
479ddddc-b1ab-4cba-a4f5-17e110772d28
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Poston, L.
86dde088-a1f1-44c1-a6e5-26f1591f6323
Wall, C.R.
fa8a9d65-ce55-4165-b3f9-52fcca87213b
Murphy, R.
e98bfddf-d951-4964-a173-d82afedc02a6
Cutfield, Wayne
a01589bd-5b82-49fa-89e1-137e6f59e24d
Kenealy, T.
f88dc737-bdd7-40c4-af80-d3a882cc203e
Kenny, L.C.
116b46cf-fe4f-46ab-a445-c7564b0e7f23
Baker, Philip N.
e1cd37f8-ad89-4ec9-852a-0de07468abab

Boyle, V.T., Thorstensen, E.B., Thompson, J.M.D., Mitchell, E.A., Godfrey, Keith, Poston, L., Wall, C.R., Murphy, R., Cutfield, Wayne, Kenealy, T., Kenny, L.C. and Baker, Philip N. (2017) The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. International Journal of Obesity, 41, 1755–1760. (doi:10.1038/ijo.2017.182).

Record type: Article

Abstract

BACKGROUND: Vitamin D insufficiency (defined as <75 nmol/l) is widespread amongst pregnant women around the world and has been proposed to influence offspring outcomes in childhood and into adult life, including adiposity and allergy. Disorders including asthma and eczema are on the rise amongst children. Our aim was to investigate the relationship between maternal 25-hydroxyvitamin D status in pregnancy and offspring adiposity, asthma and eczema in childhood. SUBJECTS AND METHODS: Maternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks’ gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints (SCOPE) cohort study. The offspring of 1208 mothers were followed up at age 5–6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedence) and history of asthma and eczema. Multivariable analysis controlled for maternal BMI, age and sex of the child and season of serum sampling. RESULTS: Complete data were available for 922 mother-child pairs. Each 10 nmol/l increase in maternal 25-hydroxyvitamin D concentration at 15 weeks’ gestation was associated with a decrease in offspring PBF of 0.2% (95% CI 0.04–0.36% P=0.01) after adjustment for confounders, but was not related to child BMI z-score. Maternal mean (±s.d.) 25-hydroxyvitamin D concentration was similar in children who did and did not have asthma (71.7±26.1 vs 73.3±27.1 nmol/l P=0.5), severe asthma (68.6±28.6 vs 73.3±26.8 nmol/l P=0.2) and eczema (71.9±27.0 vs 73.2±27.0 nmol/l P=0.5). CONCLUSIONS: The finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials.

Text
ijo2017182a - Accepted Manuscript
Download (771kB)

More information

Accepted/In Press date: 17 May 2017
e-pub ahead of print date: 4 August 2017
Published date: December 2017

Identifiers

Local EPrints ID: 412975
URI: https://eprints.soton.ac.uk/id/eprint/412975
ISSN: 0307-0565
PURE UUID: efbdd4f0-781e-4b17-9cc4-9a82beb02240
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 10 Aug 2017 16:30
Last modified: 14 Mar 2019 05:41

Export record

Altmetrics

Contributors

Author: V.T. Boyle
Author: E.B. Thorstensen
Author: J.M.D. Thompson
Author: E.A. Mitchell
Author: Keith Godfrey ORCID iD
Author: L. Poston
Author: C.R. Wall
Author: R. Murphy
Author: Wayne Cutfield
Author: T. Kenealy
Author: L.C. Kenny
Author: Philip N. Baker

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×