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Prognostic significance and correlation to gene expression profile of EZH2 mutations in diffuse large B‐cell lymphoma (DLBL) in 2 large prospective studies

Prognostic significance and correlation to gene expression profile of EZH2 mutations in diffuse large B‐cell lymphoma (DLBL) in 2 large prospective studies
Prognostic significance and correlation to gene expression profile of EZH2 mutations in diffuse large B‐cell lymphoma (DLBL) in 2 large prospective studies
EZH2, a histone methyl transferase subunit of Polycomb repressor complex 2, is frequently mutated in DLBL. Inhibitors of EZH2 have demonstrated promising responses in early clinical trials. We examined the frequency of EZH2 mutation in 2 large prospective series of DLBL and correlated this to clinical outcomes in relation to other biological features.
0278-0232
158-159
Cummin, T.E.
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Araf, S.
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Du, M.
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Barrans, S.
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Bentley, M.A.
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Clipson, A.
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Wang, M.
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Ahmed, S.
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Rahim, T.
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Shah, C.
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Hamid, D.
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Dhondt, J.
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Maishman, T.
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Vaughan-Spickers, N.
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Pocock, C.
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Forbes, A.
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O'Callaghan, A.
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Westhead, D.R.
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Griffiths, G.O.
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Fitzgibbon, J.
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Tooze, R.M.
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Care, M.A.
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Burton, C.H.
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Davies, A.J.
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Johnson, P.W.
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Cummin, T.E.
fcce88a2-7ed7-4bde-a5f5-3f3c834382a4
Araf, S.
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Du, M.
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Barrans, S.
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Bentley, M.A.
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Clipson, A.
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Wang, M.
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Ahmed, S.
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Rahim, T.
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Shah, C.
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Hamid, D.
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Dhondt, J.
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Maishman, T.
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Vaughan-Spickers, N.
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Pocock, C.
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Forbes, A.
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O'Callaghan, A.
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Westhead, D.R.
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Griffiths, G.O.
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Fitzgibbon, J.
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Tooze, R.M.
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Care, M.A.
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Burton, C.H.
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Davies, A.J.
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Johnson, P.W.
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Cummin, T.E., Araf, S., Du, M., Barrans, S., Bentley, M.A., Clipson, A., Wang, M., Ahmed, S., Rahim, T., Shah, C., Hamid, D., Dhondt, J., Maishman, T., Vaughan-Spickers, N., Pocock, C., Forbes, A., O'Callaghan, A., Westhead, D.R., Griffiths, G.O., Fitzgibbon, J., Tooze, R.M., Care, M.A., Burton, C.H., Davies, A.J. and Johnson, P.W. (2017) Prognostic significance and correlation to gene expression profile of EZH2 mutations in diffuse large B‐cell lymphoma (DLBL) in 2 large prospective studies. Hematological Oncology, 35 (S2), 158-159. (doi:10.1002/hon.2438_13).

Record type: Meeting abstract

Abstract

EZH2, a histone methyl transferase subunit of Polycomb repressor complex 2, is frequently mutated in DLBL. Inhibitors of EZH2 have demonstrated promising responses in early clinical trials. We examined the frequency of EZH2 mutation in 2 large prospective series of DLBL and correlated this to clinical outcomes in relation to other biological features.

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e-pub ahead of print date: 7 June 2017
Published date: 2017

Identifiers

Local EPrints ID: 413091
URI: http://eprints.soton.ac.uk/id/eprint/413091
DOI: doi:10.1002/hon.2438_13
ISSN: 0278-0232
PURE UUID: 7d1c4825-4ced-47db-8b62-c411066cd6c3
ORCID for G.O. Griffiths: ORCID iD orcid.org/0000-0002-9579-8021

Catalogue record

Date deposited: 15 Aug 2017 16:30
Last modified: 16 Mar 2024 04:19

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Contributors

Author: T.E. Cummin
Author: S. Araf
Author: M. Du
Author: S. Barrans
Author: M.A. Bentley
Author: A. Clipson
Author: M. Wang
Author: S. Ahmed
Author: T. Rahim
Author: C. Shah
Author: D. Hamid
Author: J. Dhondt
Author: T. Maishman
Author: N. Vaughan-Spickers
Author: C. Pocock
Author: A. Forbes
Author: A. O'Callaghan
Author: D.R. Westhead
Author: G.O. Griffiths ORCID iD
Author: J. Fitzgibbon
Author: R.M. Tooze
Author: M.A. Care
Author: C.H. Burton
Author: A.J. Davies
Author: P.W. Johnson

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