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Differential efficacy of bortezomib in subtypes of diffuse large B‐cell lymphoma (dlbl): a prospective randomised study stratified by transcriptome profiling: remodl‐B

Differential efficacy of bortezomib in subtypes of diffuse large B‐cell lymphoma (dlbl): a prospective randomised study stratified by transcriptome profiling: remodl‐B
Differential efficacy of bortezomib in subtypes of diffuse large B‐cell lymphoma (dlbl): a prospective randomised study stratified by transcriptome profiling: remodl‐B
DLBL subtypes identified by patterns of gene expression correspond to germinal center (GCB) or activated (ABC) B‐cells like. The latter demonstrate dysregulation of the NF‐KB pathway. Outcomes of treatment with R‐CHOP are inferior for ABC DLBL in retrospective series. This study investigated whether adding bortezomib (B),
a putative NF‐KB inhibitor, can reverse this phenotype.
0278-0232
130-131
Davies, A.J.
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Barrans, S.
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Maishman, T.
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Cummin, T.E.
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Bentley, M.
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Mamot, C.
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Novak, U.
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Caddy, J.
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Hamid, D.
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Kazmi-Stokes, S.H.
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Mcmillan, A.
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Fields, P.A.
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Pocock, C.
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Kruger, A.
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Collins, G.
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Sha, C.
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Clipson, A.
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Wang, M.
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Tooze, R.M.
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Care, M.A.
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Griffiths, G.O.
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Du, M.
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Westhead, D.R.
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Burton, C.
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Jack, A.
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Johnson, P.W.
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Davies, A.J.
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Barrans, S.
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Maishman, T.
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Cummin, T.E.
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Bentley, M.
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Mamot, C.
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Novak, U.
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Caddy, J.
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Hamid, D.
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Kazmi-Stokes, S.H.
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Mcmillan, A.
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Fields, P.A.
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Pocock, C.
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Kruger, A.
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Collins, G.
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Sha, C.
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Clipson, A.
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Wang, M.
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Tooze, R.M.
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Care, M.A.
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Griffiths, G.O.
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Du, M.
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Westhead, D.R.
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Burton, C.
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Jack, A.
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Johnson, P.W.
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Davies, A.J., Barrans, S., Maishman, T., Cummin, T.E., Bentley, M., Mamot, C., Novak, U., Caddy, J., Hamid, D., Kazmi-Stokes, S.H., Mcmillan, A., Fields, P.A., Pocock, C., Kruger, A., Collins, G., Sha, C., Clipson, A., Wang, M., Tooze, R.M., Care, M.A., Griffiths, G.O., Du, M., Westhead, D.R., Burton, C., Jack, A. and Johnson, P.W. (2017) Differential efficacy of bortezomib in subtypes of diffuse large B‐cell lymphoma (dlbl): a prospective randomised study stratified by transcriptome profiling: remodl‐B. Hematological Oncology, 35 (S2), 130-131. (doi:10.1002/hon.2437_120).

Record type: Meeting abstract

Abstract

DLBL subtypes identified by patterns of gene expression correspond to germinal center (GCB) or activated (ABC) B‐cells like. The latter demonstrate dysregulation of the NF‐KB pathway. Outcomes of treatment with R‐CHOP are inferior for ABC DLBL in retrospective series. This study investigated whether adding bortezomib (B),
a putative NF‐KB inhibitor, can reverse this phenotype.

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More information

e-pub ahead of print date: 7 June 2017
Published date: June 2017

Identifiers

Local EPrints ID: 413092
URI: http://eprints.soton.ac.uk/id/eprint/413092
DOI: doi:10.1002/hon.2437_120
ISSN: 0278-0232
PURE UUID: 7388073b-1a98-412e-8be7-ea0236dc4007
ORCID for G.O. Griffiths: ORCID iD orcid.org/0000-0002-9579-8021

Catalogue record

Date deposited: 15 Aug 2017 16:30
Last modified: 16 Mar 2024 04:19

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Contributors

Author: A.J. Davies
Author: S. Barrans
Author: T. Maishman
Author: T.E. Cummin
Author: M. Bentley
Author: C. Mamot
Author: U. Novak
Author: J. Caddy
Author: D. Hamid
Author: S.H. Kazmi-Stokes
Author: A. Mcmillan
Author: P.A. Fields
Author: C. Pocock
Author: A. Kruger
Author: G. Collins
Author: C. Sha
Author: A. Clipson
Author: M. Wang
Author: R.M. Tooze
Author: M.A. Care
Author: G.O. Griffiths ORCID iD
Author: M. Du
Author: D.R. Westhead
Author: C. Burton
Author: A. Jack
Author: P.W. Johnson

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