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Design and Conduct of research and clinical trials

Design and Conduct of research and clinical trials
Design and Conduct of research and clinical trials
Key points:
* The clinical impact of research evidence relies on confidence in its quality.
* Palliative care is characterized by complex clinical situations, but clinical trials require simple clinical questions.
* The designs of explanatory and pragmatic trials depend on the clinical research question.
* Choices of study populations and standard comparators influence the generalizability of the results (i.e., external validity).
* An adequate sample size and low attrition rate influence the reliability of the study result (i.e., internal validity).
* Randomization reduces the risk of bias by overcoming confounding factors.
* Choices of clinically relevant outcome measures and patient populations are crucial for the relevance of palliative care clinical trials.
* Qualitative and other important clinical information can be included in the design of quantitative clinical trails.
* Infrastructural support is essential for adequate recruitment, data management, and research governance.
148-156
Mosby
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Byrne, Anthony
b3f1c924-7ea7-49a8-bcd1-3e83609362e3
Hood, Kerry
79d7555b-fcdd-4fe1-8344-cd9859c7cbed
Maughan, Timothy S.
2ff5497d-063a-4788-a620-23fc6473f08b
Walsh, Declan
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Byrne, Anthony
b3f1c924-7ea7-49a8-bcd1-3e83609362e3
Hood, Kerry
79d7555b-fcdd-4fe1-8344-cd9859c7cbed
Maughan, Timothy S.
2ff5497d-063a-4788-a620-23fc6473f08b
Walsh, Declan

Griffiths, Gareth, Byrne, Anthony, Hood, Kerry and Maughan, Timothy S. (2008) Design and Conduct of research and clinical trials. In, Walsh, Declan (ed.) Palliative Medicine. Mosby, pp. 148-156.

Record type: Book Section

Abstract

Key points:
* The clinical impact of research evidence relies on confidence in its quality.
* Palliative care is characterized by complex clinical situations, but clinical trials require simple clinical questions.
* The designs of explanatory and pragmatic trials depend on the clinical research question.
* Choices of study populations and standard comparators influence the generalizability of the results (i.e., external validity).
* An adequate sample size and low attrition rate influence the reliability of the study result (i.e., internal validity).
* Randomization reduces the risk of bias by overcoming confounding factors.
* Choices of clinically relevant outcome measures and patient populations are crucial for the relevance of palliative care clinical trials.
* Qualitative and other important clinical information can be included in the design of quantitative clinical trails.
* Infrastructural support is essential for adequate recruitment, data management, and research governance.

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More information

Published date: 2008

Identifiers

Local EPrints ID: 413146
URI: http://eprints.soton.ac.uk/id/eprint/413146
PURE UUID: 07a83596-05c1-42c5-97df-744360912343
ORCID for Gareth Griffiths: ORCID iD orcid.org/0000-0002-9579-8021

Catalogue record

Date deposited: 16 Aug 2017 16:30
Last modified: 12 Dec 2021 04:04

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Contributors

Author: Anthony Byrne
Author: Kerry Hood
Author: Timothy S. Maughan
Editor: Declan Walsh

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