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Customization of mechanical properties and porosity of bone tissue scaffold materials via Layer-by-Layer assembly of polymer-nanocomposite coatings

Customization of mechanical properties and porosity of bone tissue scaffold materials via Layer-by-Layer assembly of polymer-nanocomposite coatings
Customization of mechanical properties and porosity of bone tissue scaffold materials via Layer-by-Layer assembly of polymer-nanocomposite coatings

The aim of this preliminary study was to adapt Layer-by-Layer (LbL) assembly to fabricate nanocomposite coatings onto open-cell porous structures, enabling customization of mechanical properties and porosity to obtain materials suitable for bone tissue scaffold applications. LbL assembly is a well-established method for fabricating multilayer films with nanometre scale precision over thickness that is based on electrostatic attractions and involves the adsorption of oppositely charged electrolytes onto a substrate. Using LbL assembly, polymer-nanoclay composite coatings were deposited onto open-cell foam substrates. The elastic modulus of coated specimens in compression was improved from 0.078 MPa to 1.736 MPa. The results suggest that polymer-nanoclay coatings deposited via LbL assembly have the potential to improve mechanical properties of porous substrates and fabricate materials with mechanical properties comparable to that of a cancellous bone tissue upon deposition of a sufficient number of multilayers.

67-72
Materials Research Society
Ziminska, M.
a53248bb-9825-4aa4-a9ea-2701a7f618f1
Dunne, N.
a75d99c0-e037-457d-87a9-2a4aec576a25
Hamilton, A.
9088cf01-8d7f-45f0-af56-b4784227447c
Ziminska, M.
a53248bb-9825-4aa4-a9ea-2701a7f618f1
Dunne, N.
a75d99c0-e037-457d-87a9-2a4aec576a25
Hamilton, A.
9088cf01-8d7f-45f0-af56-b4784227447c

Ziminska, M., Dunne, N. and Hamilton, A. (2015) Customization of mechanical properties and porosity of bone tissue scaffold materials via Layer-by-Layer assembly of polymer-nanocomposite coatings. In Foundations of Bio/Nano Interfaces - Synthesis, Modeling, Design Principles and Applications. vol. 1793, Materials Research Society. pp. 67-72 . (doi:10.1557/opl.2015.827).

Record type: Conference or Workshop Item (Paper)

Abstract

The aim of this preliminary study was to adapt Layer-by-Layer (LbL) assembly to fabricate nanocomposite coatings onto open-cell porous structures, enabling customization of mechanical properties and porosity to obtain materials suitable for bone tissue scaffold applications. LbL assembly is a well-established method for fabricating multilayer films with nanometre scale precision over thickness that is based on electrostatic attractions and involves the adsorption of oppositely charged electrolytes onto a substrate. Using LbL assembly, polymer-nanoclay composite coatings were deposited onto open-cell foam substrates. The elastic modulus of coated specimens in compression was improved from 0.078 MPa to 1.736 MPa. The results suggest that polymer-nanoclay coatings deposited via LbL assembly have the potential to improve mechanical properties of porous substrates and fabricate materials with mechanical properties comparable to that of a cancellous bone tissue upon deposition of a sufficient number of multilayers.

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Published date: 1 October 2015
Venue - Dates: 2015 MRS Spring Meeting, , San Francisco, United States, 2015-04-06 - 2015-04-10

Identifiers

Local EPrints ID: 413156
URI: http://eprints.soton.ac.uk/id/eprint/413156
PURE UUID: 3b026872-d23c-4c35-9bc2-bf112ae53182
ORCID for A. Hamilton: ORCID iD orcid.org/0000-0003-4627-849X

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Date deposited: 16 Aug 2017 16:30
Last modified: 06 Jun 2024 01:59

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Contributors

Author: M. Ziminska
Author: N. Dunne
Author: A. Hamilton ORCID iD

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