Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat
Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat
We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression. The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family. Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex. This protein is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.
Base Sequence, Binding Sites, Blotting, Northern, COUP Transcription Factor I, DNA-Binding Proteins, HIV Long Terminal Repeat, HeLa Cells, Humans, Molecular Sequence Data, Oligonucleotide Probes, Receptors, Thyroid Hormone, Regulatory Sequences, Nucleic Acid, Repressor Proteins, T-Lymphocytes, Transcription Factors, Journal Article, Research Support, Non-U.S. Gov't
5429-5434
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Lang, G
bcf892e1-e01c-4941-9e81-ab6064d3660b
Collins, Mary
55ecf446-27b3-4fdc-ae00-b6b0c8a666d5
Latchman, D
0523ed5f-2893-4762-bee1-14d89e2b3cd6
25 October 1992
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Lang, G
bcf892e1-e01c-4941-9e81-ab6064d3660b
Collins, Mary
55ecf446-27b3-4fdc-ae00-b6b0c8a666d5
Latchman, D
0523ed5f-2893-4762-bee1-14d89e2b3cd6
Orchard, K., Lang, G, Collins, Mary and Latchman, D
(1992)
Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat.
Nucleic Acids Research, 20 (20), .
Abstract
We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression. The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family. Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex. This protein is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.
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Published date: 25 October 1992
Keywords:
Base Sequence, Binding Sites, Blotting, Northern, COUP Transcription Factor I, DNA-Binding Proteins, HIV Long Terminal Repeat, HeLa Cells, Humans, Molecular Sequence Data, Oligonucleotide Probes, Receptors, Thyroid Hormone, Regulatory Sequences, Nucleic Acid, Repressor Proteins, T-Lymphocytes, Transcription Factors, Journal Article, Research Support, Non-U.S. Gov't
Identifiers
Local EPrints ID: 413221
URI: http://eprints.soton.ac.uk/id/eprint/413221
ISSN: 0305-1048
PURE UUID: 13ab9a39-46a5-40db-a7ee-061a7a9996a8
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Date deposited: 17 Aug 2017 16:30
Last modified: 29 Jul 2022 01:39
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Contributors
Author:
K. Orchard
Author:
G Lang
Author:
Mary Collins
Author:
D Latchman
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