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Letter to the Editor. A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function

Letter to the Editor. A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function
Letter to the Editor. A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function
Chronic pulmonary complications of haematopoietic SCTs (HSCTs) include interstitial disease and bronchiolitis obliterans (BO). BO almost exclusively occurs in allograft recipients (usually 12 months post HSCT1,2) and is closely associated with chronic GvHD and a poorer outcome post HSCT. Identified risk factors for BO include older age of recipient/donor, pre-transplant lung function abnormalities, female donor for male patients and low levels of IgG.1, 2, 3 The proportion of HSCT recipients developing lung GvHD varies from 1 to 40%1, 2, 3, 4 among studies. More accurate data are required for planning controlled trials of treatments such as azithromycin, which is an effective treatment for BO post lung transplantation.5,6 We have therefore performed a retrospective study to estimate the current UK prevalence of new lung function impairment following allogeneic HSCT to help plan future prospective studies of aetiological associations or therapies for lung GvHD.
Adolescent, Adult, Aged, Allografts, Bronchiolitis Obliterans, Databases, Factual, Graft vs Host Disease, Hematologic Neoplasms, Humans, Male, Middle Aged, Respiratory Function Tests, Retrospective Studies, Stem Cell Transplantation, Letter, Multicenter Study, Research Support, Non-U.S. Gov't
0268-3369
1442-1443
Dharmagunawardena, R
67279839-29a9-4c0e-bedf-0c849b09402d
Pearce, R. M.
6fbdcd49-8819-448c-b855-3f0f37d69e06
Thomas, G
2ff54aa9-a766-416b-91ee-cf1c5be74106
Kirkland, K
e06f8a4e-7bb0-411c-8845-043a0e2d11e7
Perry, J
e1398b95-a3c2-4d77-ab11-39c6a72f7b76
Apperley, J F
f328fa9a-e8b6-4744-8bcf-ec74abc5ddc1
Medd, P
71c0119c-8e15-4b49-ac25-79e280e3fa6a
Wilson, K M O
cd8d8308-be98-4f8a-9f96-b1bf5f423700
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Jackson, G.
fcfdbe6b-0410-4492-a883-c52ef8b87763
Snowden, J A
e61be132-15ba-465f-8cec-c547bed8c02c
Cook, G
fbf121a4-8973-4033-8759-81f517347b6e
Brown, J.S.
147883c0-566e-4ac1-b85b-e413e709734d
Dharmagunawardena, R
67279839-29a9-4c0e-bedf-0c849b09402d
Pearce, R. M.
6fbdcd49-8819-448c-b855-3f0f37d69e06
Thomas, G
2ff54aa9-a766-416b-91ee-cf1c5be74106
Kirkland, K
e06f8a4e-7bb0-411c-8845-043a0e2d11e7
Perry, J
e1398b95-a3c2-4d77-ab11-39c6a72f7b76
Apperley, J F
f328fa9a-e8b6-4744-8bcf-ec74abc5ddc1
Medd, P
71c0119c-8e15-4b49-ac25-79e280e3fa6a
Wilson, K M O
cd8d8308-be98-4f8a-9f96-b1bf5f423700
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Jackson, G.
fcfdbe6b-0410-4492-a883-c52ef8b87763
Snowden, J A
e61be132-15ba-465f-8cec-c547bed8c02c
Cook, G
fbf121a4-8973-4033-8759-81f517347b6e
Brown, J.S.
147883c0-566e-4ac1-b85b-e413e709734d

Dharmagunawardena, R, Pearce, R. M., Thomas, G, Kirkland, K, Perry, J, Apperley, J F, Medd, P, Wilson, K M O, Orchard, K., Jackson, G., Snowden, J A, Cook, G and Brown, J.S. (2014) Letter to the Editor. A retrospective multi-centre study of the effects of allogeneic haematopoietic SCT on pulmonary function. Bone Marrow Transplantation, 49 (11), 1442-1443. (doi:10.1038/bmt.2014.154).

Record type: Article

Abstract

Chronic pulmonary complications of haematopoietic SCTs (HSCTs) include interstitial disease and bronchiolitis obliterans (BO). BO almost exclusively occurs in allograft recipients (usually 12 months post HSCT1,2) and is closely associated with chronic GvHD and a poorer outcome post HSCT. Identified risk factors for BO include older age of recipient/donor, pre-transplant lung function abnormalities, female donor for male patients and low levels of IgG.1, 2, 3 The proportion of HSCT recipients developing lung GvHD varies from 1 to 40%1, 2, 3, 4 among studies. More accurate data are required for planning controlled trials of treatments such as azithromycin, which is an effective treatment for BO post lung transplantation.5,6 We have therefore performed a retrospective study to estimate the current UK prevalence of new lung function impairment following allogeneic HSCT to help plan future prospective studies of aetiological associations or therapies for lung GvHD.

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More information

Published date: November 2014
Keywords: Adolescent, Adult, Aged, Allografts, Bronchiolitis Obliterans, Databases, Factual, Graft vs Host Disease, Hematologic Neoplasms, Humans, Male, Middle Aged, Respiratory Function Tests, Retrospective Studies, Stem Cell Transplantation, Letter, Multicenter Study, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 413225
URI: http://eprints.soton.ac.uk/id/eprint/413225
ISSN: 0268-3369
PURE UUID: 181f5177-ffea-4bef-9af9-4f451adc94bd
ORCID for K. Orchard: ORCID iD orcid.org/0000-0003-2276-3925

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Date deposited: 17 Aug 2017 16:30
Last modified: 16 Mar 2024 03:26

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Contributors

Author: R Dharmagunawardena
Author: R. M. Pearce
Author: G Thomas
Author: K Kirkland
Author: J Perry
Author: J F Apperley
Author: P Medd
Author: K M O Wilson
Author: K. Orchard ORCID iD
Author: G. Jackson
Author: J A Snowden
Author: G Cook
Author: J.S. Brown

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