The University of Southampton
University of Southampton Institutional Repository

Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults

Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults
Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults

BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.

METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.

RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.

CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.

Adult, Case-Control Studies, Comorbidity, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Organ Size, Prefrontal Cortex, Tic Disorders, Tics, Tourette Syndrome, Journal Article, Research Support, Non-U.S. Gov't
0022-3999
84-87
Ganos, Christos
b79910d0-7d4b-4d5a-a051-b82cfb64dcea
Kühn, Simone
84836c26-cb84-4545-ad9f-6758da227371
Kahl, Ursula
8eb7f05d-54f9-4825-8756-dc4b3004405e
Schunke, Odette
aa9feb34-80a8-463a-ac58-3b2baba3826a
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Bäumer, Tobias
90576a00-054a-4ab7-952e-d50b175f4cec
Thomalla, Götz
c4a9f295-d5b2-4e96-b725-fbea275ead30
Haggard, Patrick
b68055e6-ac9c-4422-9d2b-32d7d851fb7a
Münchau, Alexander
3254c1b7-9fd4-417d-96e2-b7bc1fe3c736
Ganos, Christos
b79910d0-7d4b-4d5a-a051-b82cfb64dcea
Kühn, Simone
84836c26-cb84-4545-ad9f-6758da227371
Kahl, Ursula
8eb7f05d-54f9-4825-8756-dc4b3004405e
Schunke, Odette
aa9feb34-80a8-463a-ac58-3b2baba3826a
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Bäumer, Tobias
90576a00-054a-4ab7-952e-d50b175f4cec
Thomalla, Götz
c4a9f295-d5b2-4e96-b725-fbea275ead30
Haggard, Patrick
b68055e6-ac9c-4422-9d2b-32d7d851fb7a
Münchau, Alexander
3254c1b7-9fd4-417d-96e2-b7bc1fe3c736

Ganos, Christos, Kühn, Simone, Kahl, Ursula, Schunke, Odette, Brandt, Valerie, Bäumer, Tobias, Thomalla, Götz, Haggard, Patrick and Münchau, Alexander (2014) Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults. Journal of Psychosomatic Research, 76 (1), 84-87. (doi:10.1016/j.jpsychores.2013.10.014).

Record type: Article

Abstract

BACKGROUND: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.

METHODS: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.

RESULTS: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.

CONCLUSION: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.

Full text not available from this repository.

More information

Accepted/In Press date: 24 October 2013
e-pub ahead of print date: 1 November 2013
Published date: January 2014
Additional Information: © 2013.
Keywords: Adult, Case-Control Studies, Comorbidity, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Organ Size, Prefrontal Cortex, Tic Disorders, Tics, Tourette Syndrome, Journal Article, Research Support, Non-U.S. Gov't

Identifiers

Local EPrints ID: 413289
URI: https://eprints.soton.ac.uk/id/eprint/413289
ISSN: 0022-3999
PURE UUID: dd34793e-df71-433e-a8fe-a9f65604c328

Catalogue record

Date deposited: 18 Aug 2017 16:32
Last modified: 13 Mar 2019 20:11

Export record

Altmetrics

Contributors

Author: Christos Ganos
Author: Simone Kühn
Author: Ursula Kahl
Author: Odette Schunke
Author: Valerie Brandt
Author: Tobias Bäumer
Author: Götz Thomalla
Author: Patrick Haggard
Author: Alexander Münchau

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×