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Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition.

Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition.
Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition.
Background: early introduction of peanut is an effective strategy to prevent peanut allergy in high-risk infants; however, feasibility and effects on growth and nutritional intake are unknown.

Objective: we sought to evaluate the feasibility of introducing peanut in infancy and explore effects on growth and nutritional intake up to age 60 months.

Methods: in the Learning Early About Peanut Allergy trial, 640 atopic infants aged 4 to 11 months were randomly assigned to consume (6 g peanut protein per week) or avoid peanut until age 60 months. Peanut consumption and early feeding practices were assessed by questionnaire. Dietary intake was evaluated with prospective food diaries. Anthropometric measurements were taken at all study visits.

Results: peanut was successfully introduced and consumed until 60 months, with median peanut protein intake of 7.5 g/wk (interquartile range, 6.0-9.0 g/wk) in the consumption group compared with 0 g in the avoidance group. Introduction of peanut in breast-feeding infants did not affect the duration of breast-feeding. There were no differences in anthropometric measurements or energy intakes between groups at any visits. Regular peanut consumption led to differences in dietary intakes. Consumers had higher intakes of fat and avoiders had higher carbohydrate intakes; differences were greatest at the upper quartiles of peanut consumption. Protein intakes remained consistent between groups.

Conclusions: ntroduction of peanut proved feasible in infants at high risk of peanut allergy and did not affect the duration of breast-feeding nor impact negatively on growth or nutrition. Energy balance was achieved in both groups through variations in intakes from fat and carbohydrate while protein homeostasis was maintained.
0091-6749
1108-1118
Feeney, Mary
29a6a117-af58-431f-90ad-d29495c665c8
Du Toit, George
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Roberts, Graham
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Sayre, Peter H.
d9839665-ad89-43ff-b4fd-1f048446a182
Lawson, Kaitie
072d7e3a-a8b2-4cc8-890d-788eddba685c
Bahnson, Henry
9154ef1a-66e5-4738-98ee-ca46afeda43c
Sever, Michelle L.
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Radulovic, Suzana
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Plaut, Marshall
d6491653-2a2f-4a73-bbfa-cb9b541fac46
Lack, Gideon
cac030a2-c358-4880-a91d-d67d06e8e321
Feeney, Mary
29a6a117-af58-431f-90ad-d29495c665c8
Du Toit, George
7930b820-e6f7-4c4c-866c-4334017d1106
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Sayre, Peter H.
d9839665-ad89-43ff-b4fd-1f048446a182
Lawson, Kaitie
072d7e3a-a8b2-4cc8-890d-788eddba685c
Bahnson, Henry
9154ef1a-66e5-4738-98ee-ca46afeda43c
Sever, Michelle L.
77ce753e-b94e-4304-8e98-01719887348e
Radulovic, Suzana
8e9bce98-67a2-4999-9898-ccae71e55aa3
Plaut, Marshall
d6491653-2a2f-4a73-bbfa-cb9b541fac46
Lack, Gideon
cac030a2-c358-4880-a91d-d67d06e8e321

Feeney, Mary, Du Toit, George, Roberts, Graham, Sayre, Peter H., Lawson, Kaitie, Bahnson, Henry, Sever, Michelle L., Radulovic, Suzana, Plaut, Marshall and Lack, Gideon (2016) Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition. Journal of Allergy and Clinical Immunology, 138 (4), 1108-1118. (doi:10.1016/j.jaci.2016.04.016).

Record type: Article

Abstract

Background: early introduction of peanut is an effective strategy to prevent peanut allergy in high-risk infants; however, feasibility and effects on growth and nutritional intake are unknown.

Objective: we sought to evaluate the feasibility of introducing peanut in infancy and explore effects on growth and nutritional intake up to age 60 months.

Methods: in the Learning Early About Peanut Allergy trial, 640 atopic infants aged 4 to 11 months were randomly assigned to consume (6 g peanut protein per week) or avoid peanut until age 60 months. Peanut consumption and early feeding practices were assessed by questionnaire. Dietary intake was evaluated with prospective food diaries. Anthropometric measurements were taken at all study visits.

Results: peanut was successfully introduced and consumed until 60 months, with median peanut protein intake of 7.5 g/wk (interquartile range, 6.0-9.0 g/wk) in the consumption group compared with 0 g in the avoidance group. Introduction of peanut in breast-feeding infants did not affect the duration of breast-feeding. There were no differences in anthropometric measurements or energy intakes between groups at any visits. Regular peanut consumption led to differences in dietary intakes. Consumers had higher intakes of fat and avoiders had higher carbohydrate intakes; differences were greatest at the upper quartiles of peanut consumption. Protein intakes remained consistent between groups.

Conclusions: ntroduction of peanut proved feasible in infants at high risk of peanut allergy and did not affect the duration of breast-feeding nor impact negatively on growth or nutrition. Energy balance was achieved in both groups through variations in intakes from fat and carbohydrate while protein homeostasis was maintained.

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Feeney LEAP nutrition JACI 2016
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Accepted/In Press date: 13 April 2016
e-pub ahead of print date: 10 June 2016
Published date: October 2016

Identifiers

Local EPrints ID: 413305
URI: http://eprints.soton.ac.uk/id/eprint/413305
ISSN: 0091-6749
PURE UUID: 89e75f7c-ff6b-4497-93dd-5ea1f4fdcdfa
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 21 Aug 2017 16:31
Last modified: 18 Feb 2021 17:04

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Contributors

Author: Mary Feeney
Author: George Du Toit
Author: Graham Roberts ORCID iD
Author: Peter H. Sayre
Author: Kaitie Lawson
Author: Henry Bahnson
Author: Michelle L. Sever
Author: Suzana Radulovic
Author: Marshall Plaut
Author: Gideon Lack

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