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MAIT cells are activated during human viral infections

MAIT cells are activated during human viral infections
MAIT cells are activated during human viral infections

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

Journal Article
van Wilgenburg, Bonnie
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Scherwitzl, Iris
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Hutchinson, Edward C.
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Leng, Tianqi
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Kurioka, Ayako
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Kulicke, Corinna
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de Lara, Catherine
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Cole, Suzanne
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Vasanawathana, Sirijitt
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Limpitikul, Wannee
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Malasit, Prida
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Young, Duncan
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Denney, Laura
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Moore, Michael D.
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Fabris, Paolo
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Giordani, Maria Teresa
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Oo, Ye Htun
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Laidlaw, Stephen M.
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Dustin, Lynn B.
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Ho, Ling-Pei
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Thompson, Fiona M.
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Ramamurthy, Narayan
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Mongkolsapaya, Juthathip
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Willberg, Christian B.
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Screaton, Gavin R.
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Klenerman, Paul
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STOP-HCV Consortium
van Wilgenburg, Bonnie
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Scherwitzl, Iris
20aa3ffd-a3b3-4564-a4fe-f24d1a8a952e
Hutchinson, Edward C.
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Leng, Tianqi
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Kurioka, Ayako
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Kulicke, Corinna
3561567f-18b2-443e-9d80-e19dd13e4404
de Lara, Catherine
62dbce1d-40b8-4235-a157-bfff1bf612b7
Cole, Suzanne
8494c030-c8bd-45c7-98a9-fa8727f82bae
Vasanawathana, Sirijitt
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Limpitikul, Wannee
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Malasit, Prida
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Young, Duncan
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Denney, Laura
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Moore, Michael D.
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Fabris, Paolo
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Giordani, Maria Teresa
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Oo, Ye Htun
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Laidlaw, Stephen M.
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Dustin, Lynn B.
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Ho, Ling-Pei
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Thompson, Fiona M.
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Ramamurthy, Narayan
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Mongkolsapaya, Juthathip
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Willberg, Christian B.
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Screaton, Gavin R.
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Klenerman, Paul
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van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R. and Klenerman, Paul , STOP-HCV Consortium (2016) MAIT cells are activated during human viral infections. Nature Communications, 7. (doi:10.1038/ncomms11653).

Record type: Article

Abstract

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

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Accepted/In Press date: 7 April 2016
e-pub ahead of print date: 23 June 2016
Keywords: Journal Article

Identifiers

Local EPrints ID: 413405
URI: https://eprints.soton.ac.uk/id/eprint/413405
PURE UUID: 4fdf36b5-cfb9-4e8c-ab16-386ab3e09409
ORCID for Michael D. Moore: ORCID iD orcid.org/0000-0002-5127-4509

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Date deposited: 23 Aug 2017 16:32
Last modified: 12 Nov 2019 01:47

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Contributors

Author: Bonnie van Wilgenburg
Author: Iris Scherwitzl
Author: Edward C. Hutchinson
Author: Tianqi Leng
Author: Ayako Kurioka
Author: Corinna Kulicke
Author: Catherine de Lara
Author: Suzanne Cole
Author: Sirijitt Vasanawathana
Author: Wannee Limpitikul
Author: Prida Malasit
Author: Duncan Young
Author: Laura Denney
Author: Paolo Fabris
Author: Maria Teresa Giordani
Author: Ye Htun Oo
Author: Stephen M. Laidlaw
Author: Lynn B. Dustin
Author: Ling-Pei Ho
Author: Fiona M. Thompson
Author: Narayan Ramamurthy
Author: Juthathip Mongkolsapaya
Author: Christian B. Willberg
Author: Gavin R. Screaton
Author: Paul Klenerman

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