The University of Southampton
University of Southampton Institutional Repository

Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase

Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase
Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase

Pre-conditioning is an exciting physiological phenomenon that, despite great efforts, has so far resisted translation to mainstream clinical medicine. Many potential triggers (e.g., ischemia of the organ in question or a remote organ, many different drugs) have been investigated, but recent work has implicated activation of mitochondrial aldehyde dehydrogenase (ALDH2) as central to the process. A genetic polymorphism, known as ALDH2*2, is common worldwide (present in up to 40% of Han Chinese people) and produces a functionally different enzyme. The authors used a variety of protocols in the human ischemic forearm model, in participants with both enzyme types, to assess cytoprotection with low-dose sodium nitrite and attempt to further elucidate the role of ALDH2.

Journal Article
2452-302X
13-21
Ormerod, Julian O.M.
0c5adcde-df48-48ef-bbad-d40e53fd77fe
Evans, Jonathan D.W.
15536695-38f8-4678-a90c-9b20079c05d9
Contractor, Hussain
c99fc2e6-da30-4f38-8a55-d2330d167b5b
Beretta, Matteo
39b2a753-86b0-4448-b3f3-c35727cd7250
Arif, Sayqa
ed43541d-4eaf-4397-9028-88b9571effff
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Mayer, Bernd
f013d1b2-f297-4b06-ba77-b27ade11d73d
Kharbanda, Rajesh K.
5feec5eb-ed56-431e-89ac-2777512bf005
Frenneaux, Michael P.
82824b6d-51f1-4b31-9f7a-5b4746d59833
Ashrafian, Houman
5bfc2cf7-6f24-4e24-9f9b-d217cfc94566
Ormerod, Julian O.M.
0c5adcde-df48-48ef-bbad-d40e53fd77fe
Evans, Jonathan D.W.
15536695-38f8-4678-a90c-9b20079c05d9
Contractor, Hussain
c99fc2e6-da30-4f38-8a55-d2330d167b5b
Beretta, Matteo
39b2a753-86b0-4448-b3f3-c35727cd7250
Arif, Sayqa
ed43541d-4eaf-4397-9028-88b9571effff
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Mayer, Bernd
f013d1b2-f297-4b06-ba77-b27ade11d73d
Kharbanda, Rajesh K.
5feec5eb-ed56-431e-89ac-2777512bf005
Frenneaux, Michael P.
82824b6d-51f1-4b31-9f7a-5b4746d59833
Ashrafian, Houman
5bfc2cf7-6f24-4e24-9f9b-d217cfc94566

Ormerod, Julian O.M., Evans, Jonathan D.W., Contractor, Hussain, Beretta, Matteo, Arif, Sayqa, Fernandez, Bernadette O., Feelisch, Martin, Mayer, Bernd, Kharbanda, Rajesh K., Frenneaux, Michael P. and Ashrafian, Houman (2017) Human second window pre-conditioning and post-conditioning by nitrite is influenced by a common polymorphism in mitochondrial aldehyde dehydrogenase. JACC. Basic to translational science, 2 (1), 13-21. (doi:10.1016/j.jacbts.2016.11.006).

Record type: Article

Abstract

Pre-conditioning is an exciting physiological phenomenon that, despite great efforts, has so far resisted translation to mainstream clinical medicine. Many potential triggers (e.g., ischemia of the organ in question or a remote organ, many different drugs) have been investigated, but recent work has implicated activation of mitochondrial aldehyde dehydrogenase (ALDH2) as central to the process. A genetic polymorphism, known as ALDH2*2, is common worldwide (present in up to 40% of Han Chinese people) and produces a functionally different enzyme. The authors used a variety of protocols in the human ischemic forearm model, in participants with both enzyme types, to assess cytoprotection with low-dose sodium nitrite and attempt to further elucidate the role of ALDH2.

Text
1-s2.0-S2452302X16301723-main - Version of Record
Available under License Creative Commons Attribution.
Download (981kB)

More information

Accepted/In Press date: 4 November 2016
e-pub ahead of print date: 15 February 2017
Published date: February 2017
Keywords: Journal Article

Identifiers

Local EPrints ID: 413478
URI: https://eprints.soton.ac.uk/id/eprint/413478
ISSN: 2452-302X
PURE UUID: dd086f60-dd4c-4cc8-84df-0e86ab2d4479
ORCID for Bernadette O. Fernandez: ORCID iD orcid.org/0000-0001-6337-0381
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 24 Aug 2017 16:30
Last modified: 10 Dec 2019 01:37

Export record

Altmetrics

Contributors

Author: Julian O.M. Ormerod
Author: Jonathan D.W. Evans
Author: Hussain Contractor
Author: Matteo Beretta
Author: Sayqa Arif
Author: Bernadette O. Fernandez ORCID iD
Author: Martin Feelisch ORCID iD
Author: Bernd Mayer
Author: Rajesh K. Kharbanda
Author: Michael P. Frenneaux
Author: Houman Ashrafian

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×