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The mutational signature of chronic lymphocytic leukemia

The mutational signature of chronic lymphocytic leukemia
The mutational signature of chronic lymphocytic leukemia

Advances in next-generation sequencing technologies continue to unravel the cancer genome, identifying key biological pathways important for disease pathogenesis and clinically relevant genetic lesions. These studies have provided unprecedented resolution of the cancer genome, facilitating significant advances in the ability to detect many cancers, and predict patients who will develop an aggressive disease or respond poorly to treatment. The mature B-cell neoplasm chronic lymphocytic leukaemia remains at the forefront of these genomic analyses, largely due its protracted natural history and the accessibility to suitable material for study. We now possess a comprehensive view of the genomic copy number mutational landscape of the disease, as well as a detail description of clonal evolution, and the molecular mechanisms that drive the acquisition of genomic lesions and more broadly, genomic complexity. Here, recent genomic insights with associated biological and clinical implications will be reviewed.

Review, Journal Article
1470-8728
3725-3740
Parker, Helen
33e0cd81-d45f-49bc-9539-09345d79d895
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Parker, Helen
33e0cd81-d45f-49bc-9539-09345d79d895
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f

Parker, Helen and Strefford, Jonathan C. (2016) The mutational signature of chronic lymphocytic leukemia. Biochemical Journal, 473 (21), 3725-3740. (doi:10.1042/BCJ20160256).

Record type: Review

Abstract

Advances in next-generation sequencing technologies continue to unravel the cancer genome, identifying key biological pathways important for disease pathogenesis and clinically relevant genetic lesions. These studies have provided unprecedented resolution of the cancer genome, facilitating significant advances in the ability to detect many cancers, and predict patients who will develop an aggressive disease or respond poorly to treatment. The mature B-cell neoplasm chronic lymphocytic leukaemia remains at the forefront of these genomic analyses, largely due its protracted natural history and the accessibility to suitable material for study. We now possess a comprehensive view of the genomic copy number mutational landscape of the disease, as well as a detail description of clonal evolution, and the molecular mechanisms that drive the acquisition of genomic lesions and more broadly, genomic complexity. Here, recent genomic insights with associated biological and clinical implications will be reviewed.

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Parker_etal_Review_2016_resubmission_v1_unmarked)figures_pure - Accepted Manuscript
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More information

Accepted/In Press date: 23 August 2016
e-pub ahead of print date: 27 October 2016
Published date: November 2016
Keywords: Review, Journal Article

Identifiers

Local EPrints ID: 413491
URI: http://eprints.soton.ac.uk/id/eprint/413491
ISSN: 1470-8728
PURE UUID: a5737829-1b72-4305-b2cb-72ae66ab6f21
ORCID for Helen Parker: ORCID iD orcid.org/0000-0001-8308-9781
ORCID for Jonathan C. Strefford: ORCID iD orcid.org/0000-0002-0972-2881

Catalogue record

Date deposited: 24 Aug 2017 16:31
Last modified: 16 Mar 2024 05:12

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