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Resistance is futile: Targeting the inhibitory FcγRIIB (CD32B) to maximize immunotherapy

Resistance is futile: Targeting the inhibitory FcγRIIB (CD32B) to maximize immunotherapy
Resistance is futile: Targeting the inhibitory FcγRIIB (CD32B) to maximize immunotherapy

Monoclonal antibodies (mAb) are central to the treatment of several types of malignancy. However, these reagents are subject to particular types of resistance. Several resistance mechanisms are regulated by the inhibitory FcγRIIB. We recently developed mAbs to block FcγRIIB and provided in vivo proof-of-concept for their ability to overcome FcγRIIB-mediated resistance.

Journal Article
2162-4011
e1069939
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Cragg, Mark S
ec97f80e-f3c8-49b7-a960-20dff648b78c
Frendéus, Björn
c960f7ce-006a-4ea9-8aac-f6f0304a746c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Cragg, Mark S
ec97f80e-f3c8-49b7-a960-20dff648b78c
Frendéus, Björn
c960f7ce-006a-4ea9-8aac-f6f0304a746c

Roghanian, Ali, Cragg, Mark S and Frendéus, Björn (2016) Resistance is futile: Targeting the inhibitory FcγRIIB (CD32B) to maximize immunotherapy. OncoImmunology, 5 (2), e1069939. (doi:10.1080/2162402X.2015.1069939).

Record type: Article

Abstract

Monoclonal antibodies (mAb) are central to the treatment of several types of malignancy. However, these reagents are subject to particular types of resistance. Several resistance mechanisms are regulated by the inhibitory FcγRIIB. We recently developed mAbs to block FcγRIIB and provided in vivo proof-of-concept for their ability to overcome FcγRIIB-mediated resistance.

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More information

Published date: February 2016
Keywords: Journal Article

Identifiers

Local EPrints ID: 413678
URI: http://eprints.soton.ac.uk/id/eprint/413678
DOI: doi:10.1080/2162402X.2015.1069939
ISSN: 2162-4011
PURE UUID: de37fa51-d81a-4dcf-b5c2-a9ef58336509
ORCID for Ali Roghanian: ORCID iD orcid.org/0000-0003-1316-4218
ORCID for Mark S Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 31 Aug 2017 16:31
Last modified: 16 Mar 2024 04:01

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Contributors

Author: Ali Roghanian ORCID iD
Author: Mark S Cragg ORCID iD
Author: Björn Frendéus

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