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Placental lipid and fatty acid transfer in maternal overnutrition

Placental lipid and fatty acid transfer in maternal overnutrition
Placental lipid and fatty acid transfer in maternal overnutrition

BACKGROUND: The increasing incidence of childhood obesity is a significant public health challenge, the consequences of which extend across the life course.

SUMMARY: Diet and exercise are clearly the major contributors to childhood obesity, but the factors predisposing to obesity may become established in the womb. Worryingly maternal overnutrition, in particular when it leads to obesity and diabetes, perpetuate an intergenerational cycle of obesity through its effects on placental function and fetal metabolism. This review will address the ways in which the placental lipid and fatty acid transfer may lay the foundations for obesity in the context of maternal overnutrition. Key Messages: (1) Metabolic changes associated with maternal obesity affect placental nutrient handling. (2) Altered placental nutrient handling may induce pro-adipogenic changes in the fetus, in particular increased fetal insulin. (3) Understanding the effects of maternal obesity on the placenta will aid the development of effective interventions to optimise pregnancy outcomes.

Journal Article
0250-6807
228-231
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Desoye, Gernot
905d057f-c298-423a-9244-78b789ecdd68
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Desoye, Gernot
905d057f-c298-423a-9244-78b789ecdd68

Lewis, Rohan M. and Desoye, Gernot (2017) Placental lipid and fatty acid transfer in maternal overnutrition. Annals of Nutrition and Metabolism, 70 (3), 228-231. (doi:10.1159/000463397).

Record type: Review

Abstract

BACKGROUND: The increasing incidence of childhood obesity is a significant public health challenge, the consequences of which extend across the life course.

SUMMARY: Diet and exercise are clearly the major contributors to childhood obesity, but the factors predisposing to obesity may become established in the womb. Worryingly maternal overnutrition, in particular when it leads to obesity and diabetes, perpetuate an intergenerational cycle of obesity through its effects on placental function and fetal metabolism. This review will address the ways in which the placental lipid and fatty acid transfer may lay the foundations for obesity in the context of maternal overnutrition. Key Messages: (1) Metabolic changes associated with maternal obesity affect placental nutrient handling. (2) Altered placental nutrient handling may induce pro-adipogenic changes in the fetus, in particular increased fetal insulin. (3) Understanding the effects of maternal obesity on the placenta will aid the development of effective interventions to optimise pregnancy outcomes.

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More information

Accepted/In Press date: 17 February 2017
e-pub ahead of print date: 17 March 2017
Published date: July 2017
Keywords: Journal Article

Identifiers

Local EPrints ID: 413709
URI: http://eprints.soton.ac.uk/id/eprint/413709
ISSN: 0250-6807
PURE UUID: 8ac4c144-9b33-4d12-b824-5d0bc4afa253
ORCID for Rohan M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104

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Date deposited: 31 Aug 2017 16:32
Last modified: 16 Mar 2024 03:21

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Contributors

Author: Rohan M. Lewis ORCID iD
Author: Gernot Desoye

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