The University of Southampton
University of Southampton Institutional Repository

Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): Retrospective study of the EBMT Lymphoma Working Party

Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): Retrospective study of the EBMT Lymphoma Working Party
Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): Retrospective study of the EBMT Lymphoma Working Party

Relapse remains the most common cause of treatment failure in patients receiving autologous stem cell transplantation (ASCT) for follicular lymphoma (FL). The aim of this study was to evaluate the effect of adding radioimmunotherapy or rituximab (R) to BEAM (carmustine, etoposide, ara-c, melphalan) high-dose therapy for ASCT in patients with relapsed FL. Using the European Society for Blood and Marrow Transplantation registry, we conducted a cohort comparison of BEAM (n=1973), Zevalin-BEAM (Z-BEAM) (n=207) and R-BEAM (n=179) and also a matched-cohort analysis of BEAM vs Z-BEAM including 282 and 154 patients, respectively. BEAM, Z-BEAM and R-BEAM groups were well balanced for age, time from diagnosis to ASCT and disease status at ASCT. The cumulative incidences of relapse (IR) at 2 years were 34, 34 and 32% for Z-BEAM, R-BEAM and BEAM, respectively. By multivariate analysis, there were no significant differences with Z-BEAM or R-BEAM compared with BEAM for IR, non-relapse mortality, event-free survival or overall survival. With the caveat that the limitations of registry analyses have to be taken into account, this study does not support adding radioimmunotherapy or R to BEAM in ASCT for relapsed FL. However, we cannot rule out the existence a particular subset of patients who could benefit from Z-BEAM conditioning that cannot be identified in our series, and this should be tested in a randomized trial.Bone Marrow Transplantation advance online publication, 22 May 2017; doi:10.1038/bmt.2017.88.

Journal Article
0268-3369
1120-1125
Bento, L.
53c1b424-1a4c-44d3-a0a6-c44baebd6a7e
Boumendil, A.
60262ae7-b2ab-407c-a1ae-30d092d708c4
Finel, H.
22f6ad33-81c4-4109-9a27-670acd4cfecd
Le Gouill, S.
0052eb45-1ca0-4725-a328-8f4a14679200
Amorim, S.
d4a5ad52-47a9-4418-a67d-248e67092f2d
Monjanel, H.
4380e5a0-34ef-4f29-99d2-25a885497c55
Bouabdallah, R
4fca9e0a-6a9f-4788-bfc9-e27da4d544c1
Bay, J.O.
91ef8d6a-dae4-4625-b2ac-5ad151bf5d88
Nicolas-Virelizier, E.
dba49b9e-ef97-4d6f-a917-a46de1a9057a
McQuaker, G.
d8732d10-e668-432a-a815-01544cf0c13f
Rossi, G.
e55ede28-0f95-4422-b279-1bd9577d3836
Johnson, R.
cb48d70e-3286-4c6d-8f13-e59186d6b432
Huynh, A.
b2188404-992b-4a3a-8095-4a6be4c6d527
Ceballos, P.
0eb68e07-c864-4b64-8e8c-11b9ca725b9e
Rambaldi, A.
bfd1d3e3-8686-4afd-a958-f41a43aa8318
Bachy, E.
20c35ad6-87a4-4cd3-89b6-10dd4395432f
Malladi, R.
edc9cf7a-521c-48a3-854c-b2319ebe9580
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Pohlreich, D.
17529e2e-9206-4063-83cc-f758a35c223b
Tilly, H.
b0a420d8-db53-4bc8-ae0b-25671bdb1b55
Bonifazi, F.
49d8ee0c-332d-4524-9612-f78404f1230e
Poiré, X.
13c77727-de6b-4f69-960e-03c808d31177
Guilhot, F.
4a1c5e8f-8082-42da-b622-b357f305e353
Haenel, A.
3a3c52be-ec91-4b51-a36a-ec38a0b31d27
Crawley, C.
f28ea906-9ef4-4eb7-89c9-3d563c843d00
Metzner, B.
73a1ce63-6cee-48cf-9099-e5a7bad1a5a8
Gribben, J.
3c29b692-6028-4e8d-bc1e-46d9986e9f23
Russell, N.H.
5b5fea25-023b-4bb4-a3d8-97c407d2223a
Damaj, G.
fa1af15b-ae76-4e4c-94b9-74ecf48a6a1b
Thomson, K.
b8c026c5-37b1-4f41-ae33-688b7d9fb8bd
Dreger, P.
c2d629f9-0538-49dd-8a23-dfac013a252d
Montoto, S.
c05d6ef0-61e9-4ab0-8e70-1facb965bbff
Bento, L.
53c1b424-1a4c-44d3-a0a6-c44baebd6a7e
Boumendil, A.
60262ae7-b2ab-407c-a1ae-30d092d708c4
Finel, H.
22f6ad33-81c4-4109-9a27-670acd4cfecd
Le Gouill, S.
0052eb45-1ca0-4725-a328-8f4a14679200
Amorim, S.
d4a5ad52-47a9-4418-a67d-248e67092f2d
Monjanel, H.
4380e5a0-34ef-4f29-99d2-25a885497c55
Bouabdallah, R
4fca9e0a-6a9f-4788-bfc9-e27da4d544c1
Bay, J.O.
91ef8d6a-dae4-4625-b2ac-5ad151bf5d88
Nicolas-Virelizier, E.
dba49b9e-ef97-4d6f-a917-a46de1a9057a
McQuaker, G.
d8732d10-e668-432a-a815-01544cf0c13f
Rossi, G.
e55ede28-0f95-4422-b279-1bd9577d3836
Johnson, R.
cb48d70e-3286-4c6d-8f13-e59186d6b432
Huynh, A.
b2188404-992b-4a3a-8095-4a6be4c6d527
Ceballos, P.
0eb68e07-c864-4b64-8e8c-11b9ca725b9e
Rambaldi, A.
bfd1d3e3-8686-4afd-a958-f41a43aa8318
Bachy, E.
20c35ad6-87a4-4cd3-89b6-10dd4395432f
Malladi, R.
edc9cf7a-521c-48a3-854c-b2319ebe9580
Orchard, K.
794654ab-d6cc-488a-ac11-c9217433c7a2
Pohlreich, D.
17529e2e-9206-4063-83cc-f758a35c223b
Tilly, H.
b0a420d8-db53-4bc8-ae0b-25671bdb1b55
Bonifazi, F.
49d8ee0c-332d-4524-9612-f78404f1230e
Poiré, X.
13c77727-de6b-4f69-960e-03c808d31177
Guilhot, F.
4a1c5e8f-8082-42da-b622-b357f305e353
Haenel, A.
3a3c52be-ec91-4b51-a36a-ec38a0b31d27
Crawley, C.
f28ea906-9ef4-4eb7-89c9-3d563c843d00
Metzner, B.
73a1ce63-6cee-48cf-9099-e5a7bad1a5a8
Gribben, J.
3c29b692-6028-4e8d-bc1e-46d9986e9f23
Russell, N.H.
5b5fea25-023b-4bb4-a3d8-97c407d2223a
Damaj, G.
fa1af15b-ae76-4e4c-94b9-74ecf48a6a1b
Thomson, K.
b8c026c5-37b1-4f41-ae33-688b7d9fb8bd
Dreger, P.
c2d629f9-0538-49dd-8a23-dfac013a252d
Montoto, S.
c05d6ef0-61e9-4ab0-8e70-1facb965bbff

Bento, L., Boumendil, A., Finel, H., Le Gouill, S., Amorim, S., Monjanel, H., Bouabdallah, R, Bay, J.O., Nicolas-Virelizier, E., McQuaker, G., Rossi, G., Johnson, R., Huynh, A., Ceballos, P., Rambaldi, A., Bachy, E., Malladi, R., Orchard, K., Pohlreich, D., Tilly, H., Bonifazi, F., Poiré, X., Guilhot, F., Haenel, A., Crawley, C., Metzner, B., Gribben, J., Russell, N.H., Damaj, G., Thomson, K., Dreger, P. and Montoto, S. (2017) Radioimmunotherapy-augmented BEAM chemotherapy vs BEAM alone as the high-dose regimen for autologous stem cell transplantation (ASCT) in relapsed follicular lymphoma (FL): Retrospective study of the EBMT Lymphoma Working Party Bone Marrow Transplantation, 52, (8), pp. 1120-1125. (doi:10.1038/bmt.2017.88).

Record type: Article

Abstract

Relapse remains the most common cause of treatment failure in patients receiving autologous stem cell transplantation (ASCT) for follicular lymphoma (FL). The aim of this study was to evaluate the effect of adding radioimmunotherapy or rituximab (R) to BEAM (carmustine, etoposide, ara-c, melphalan) high-dose therapy for ASCT in patients with relapsed FL. Using the European Society for Blood and Marrow Transplantation registry, we conducted a cohort comparison of BEAM (n=1973), Zevalin-BEAM (Z-BEAM) (n=207) and R-BEAM (n=179) and also a matched-cohort analysis of BEAM vs Z-BEAM including 282 and 154 patients, respectively. BEAM, Z-BEAM and R-BEAM groups were well balanced for age, time from diagnosis to ASCT and disease status at ASCT. The cumulative incidences of relapse (IR) at 2 years were 34, 34 and 32% for Z-BEAM, R-BEAM and BEAM, respectively. By multivariate analysis, there were no significant differences with Z-BEAM or R-BEAM compared with BEAM for IR, non-relapse mortality, event-free survival or overall survival. With the caveat that the limitations of registry analyses have to be taken into account, this study does not support adding radioimmunotherapy or R to BEAM in ASCT for relapsed FL. However, we cannot rule out the existence a particular subset of patients who could benefit from Z-BEAM conditioning that cannot be identified in our series, and this should be tested in a randomized trial.Bone Marrow Transplantation advance online publication, 22 May 2017; doi:10.1038/bmt.2017.88.

Text Revised_Manuscript (1) - Accepted Manuscript
Download (265kB)

More information

e-pub ahead of print date: 22 May 2017
Published date: 1 August 2017
Keywords: Journal Article

Identifiers

Local EPrints ID: 413729
URI: http://eprints.soton.ac.uk/id/eprint/413729
ISSN: 0268-3369
PURE UUID: bedfcb27-f3aa-40e9-b1c1-58dd9298ad96
ORCID for K. Orchard: ORCID iD orcid.org/0000-0003-2276-3925

Catalogue record

Date deposited: 01 Sep 2017 16:31
Last modified: 22 Nov 2017 05:01

Export record

Altmetrics

Contributors

Author: L. Bento
Author: A. Boumendil
Author: H. Finel
Author: S. Le Gouill
Author: S. Amorim
Author: H. Monjanel
Author: R Bouabdallah
Author: J.O. Bay
Author: E. Nicolas-Virelizier
Author: G. McQuaker
Author: G. Rossi
Author: R. Johnson
Author: A. Huynh
Author: P. Ceballos
Author: A. Rambaldi
Author: E. Bachy
Author: R. Malladi
Author: K. Orchard ORCID iD
Author: D. Pohlreich
Author: H. Tilly
Author: F. Bonifazi
Author: X. Poiré
Author: F. Guilhot
Author: A. Haenel
Author: C. Crawley
Author: B. Metzner
Author: J. Gribben
Author: N.H. Russell
Author: G. Damaj
Author: K. Thomson
Author: P. Dreger
Author: S. Montoto

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×