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Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study

Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study
Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study

INTRODUCTION: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently.

METHODS AND ANALYSIS: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ((18)FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for (18)FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.

ETHICS AND DISSEMINATION: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.

TRIAL REGISTRATION NUMBER: ISRCTN30784948; Pre-results.

Journal Article
2044-6055
Qureshi, N.R.
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Rintoul, R.C.
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Miles, K.A.
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George, S.
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Harris, S.
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Madden, J.
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Cozens, K.
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Little, L.A.
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Eichhorst, K.
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Jones, J.
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Moate, P.
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McClement, C.
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Sinclair, D.
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Wong, W.L.
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Shekhdar, J.
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Eaton, R.
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Shah, A.
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Brindle, L.
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Peebles, C.
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Banerjee, A.
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Groves, A.M.
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Kurban, L.
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Frew, A.J.
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Callister, M.E.
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Crosbie, P.
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Gleeson, F.V.
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Gilbert, F.J.
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Qureshi, N.R.
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Rintoul, R.C.
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Miles, K.A.
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George, S.
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Harris, S.
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Madden, J.
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Cozens, K.
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Little, L.A.
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Eichhorst, K.
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Jones, J.
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Moate, P.
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McClement, C.
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Sinclair, D.
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Wong, W.L.
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Shekhdar, J.
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Eaton, R.
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Shah, A.
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Brindle, L.
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Peebles, C.
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Banerjee, A.
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Dizdarevic, S.
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Groves, A.M.
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Crosbie, P.
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Gilbert, F.J.
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Qureshi, N.R., Rintoul, R.C., Miles, K.A., George, S., Harris, S., Madden, J., Cozens, K., Little, L.A., Eichhorst, K., Jones, J., Moate, P., McClement, C., Pike, L., Sinclair, D., Wong, W.L., Shekhdar, J., Eaton, R., Shah, A., Brindle, L., Peebles, C., Banerjee, A., Dizdarevic, S., Han, S., Poon, F.W., Groves, A.M., Kurban, L., Frew, A.J., Callister, M.E., Crosbie, P., Gleeson, F.V., Karunasaagarar, K., Kankam, O. and Gilbert, F.J. (2016) Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules-the SPUtNIk study. BMJ Open, 3 (1), [e000156]. (doi:10.1136/bmjresp-2016-000156).

Record type: Article

Abstract

INTRODUCTION: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently.

METHODS AND ANALYSIS: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ((18)FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for (18)FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs.

ETHICS AND DISSEMINATION: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.

TRIAL REGISTRATION NUMBER: ISRCTN30784948; Pre-results.

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Accepted/In Press date: 17 August 2016
e-pub ahead of print date: 14 October 2016
Published date: October 2016
Keywords: Journal Article

Identifiers

Local EPrints ID: 413736
URI: http://eprints.soton.ac.uk/id/eprint/413736
DOI: doi:10.1136/bmjresp-2016-000156
ISSN: 2044-6055
PURE UUID: 26368181-3def-45fd-8f22-306321b63cd4
ORCID for K. Cozens: ORCID iD orcid.org/0000-0001-9592-9100
ORCID for L. Brindle: ORCID iD orcid.org/0000-0002-8933-3754
ORCID for A. Banerjee: ORCID iD orcid.org/0000-0003-2292-4936

Catalogue record

Date deposited: 01 Sep 2017 16:31
Last modified: 16 Mar 2024 03:52

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Contributors

Author: N.R. Qureshi
Author: R.C. Rintoul
Author: K.A. Miles
Author: S. George
Author: S. Harris
Author: J. Madden
Author: K. Cozens ORCID iD
Author: L.A. Little
Author: K. Eichhorst
Author: J. Jones
Author: P. Moate
Author: C. McClement
Author: L. Pike
Author: D. Sinclair
Author: W.L. Wong
Author: J. Shekhdar
Author: R. Eaton
Author: A. Shah
Author: L. Brindle ORCID iD
Author: C. Peebles
Author: A. Banerjee ORCID iD
Author: S. Dizdarevic
Author: S. Han
Author: F.W. Poon
Author: A.M. Groves
Author: L. Kurban
Author: A.J. Frew
Author: M.E. Callister
Author: P. Crosbie
Author: F.V. Gleeson
Author: K. Karunasaagarar
Author: O. Kankam
Author: F.J. Gilbert

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